487-52-5 Butein AKSci W1236
 
 
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  W1236    AKSci Reference Standard
Butein, 98% (HPLC), powder
 
1-(2,4-Dihydroxyphenyl)-3-(3,4-dihydroxyphenyl)-2-propen-1-one
2',3,4,4'-Tetrahydroxychalcone
IDENTITY
CAS Number:487-52-5
MDL Number:MFCD00017300
MF:C15H12O5
MW:272.25
EINECS:207-659-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:234-240°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO
Application(s):EGFR
Research Area:Inflammatory

REVIEW
 Butein is a naturally occurring chalconoid found in Toxicodendron vernicifluum (or formerly Rhus verniciflua) and has beeb used as a traditional herbal medicine for its various biological activities. These include antioxidative, aldose reductase, advanced glycation endproducts inhibitory effects, suppression of NH-kappaB mediated inflammation and cancer.and anti-adipogenic effects It is also a sirtuin-activating compound, a chemical compound having an effect on sirtuins, a group of enzymes that use NAD+ to remove acetyl groups from proteins. They are caloric restriction mimetic candidates, molecules able to prevent aging-related diseases like Alzheimer's, diabetes, and obesity.

REFERENCES
[1]Lee EH, Song DG, Lee JY, Pan CH, Um BH, Jung SH. Inhibitory effect of the compounds isolated from Rhus verniciflua on aldose reductase and advanced glycation endproducts. Biol Pharm Bull. 2008 Aug;31(8):1626-30.
[2] Wang Y. The plant polyphenol butein inhibits testosterone-induced proliferation in breast cancer cells expressing aromatase. Life Sci. 2005 May 20;77(1):39-51.
[3] Gupta SC, Kim JH, Prasad S, Aggarwal BB. Regulation of survival, proliferation, invasion, angiogenesis, and metastasis of tumor cells through modulation of inflammatory pathways by nutraceuticals. Cancer Metastasis Rev. 2010 Sep;29(3):405-34.
[4] Yadav VR, Prasad S, Sung B, Aggarwal BB. The role of chalcones in suppression of NF-kappaB-mediated inflammation and cancer. Int Immunopharmacol. 2011 Mar;11(3):295-309

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 25, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Natural Products


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