Benzathine benzylpenicillin with 0.2% Polysorbate 80
IDENTITY
CAS Number:
1538-09-6
MDL Number:
MFCD00079284
MF:
C16H20N2.2C16H18N2O4S
MW:
909.13
EINECS:
216-260-5
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
98% (HPLC)
Physical Form (at 20°C):
Solid
Melting Point:
133-136°C
Long-Term Storage:
Store long-term in a cool, dry place
Note:
Contain 0.2% Polysorbate 80
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
REVIEW Benzathine benzylpenicillin is a form of penicillin antibacterial also known as benzathine penicillin. It is slowly absorbed into the circulation after intramuscular injection and hydrolysed to benzylpenicillin in vivo. It is the drug-of-choice when prolonged low concentrations of benzylpenicillin are required and appropriate, allowing prolonged antibiotic action over 2-4 weeks after a single IM dose. Specific indications for benzathine penicillin include prophylaxis of rheumatic fever and early or latent syphilis. The benzylpenicillin inhibits bacterial cell wall synthesis by binding to one or more of the penicillin-binding proteins (PBPs). This inhibits the final transpeptidation step of peptidoglycan synthesis in bacterial cell walls, thus inhibiting cell wall biosynthesis. Bacteria eventually lyse due to ongoing activity of cell wall autolytic enzymes (autolysins and murein hydrolases) while cell wall assembly is arrested.
REFERENCES
[1]
Elias, William; Price, Alison H.; Merrion, H. Joseph N,N'-Dibenzylethylenediamine penicillin: a new repository form of penicillin Antibiotics and Chemotherapy (Washington, D. C.) (1951), 1, 491-8.
[2]
Szabo, J. Lester; Edwards, Charles D.; Bruce, Wm. F. N,N'-Dibenzylethylenediamine penicillin: preparation and properties Antibiotics and Chemotherapy (Washington, D. C.) (1951), 1, 499-503.
[3]
Fletcher, A. P.; Knappett, C. R. N,N'-Dibenzylethylenediamine penicillin: a new repository form of penicillin British Medical Journal (1953), 1953, I, 188-9.
[4]
Dupin N, Farhi D. Syphilis.Presse Med. 2013 Apr;42(4 Pt 1):446-53.
[5]
De Holanda E Silva KG, Barratt G, De Oliveira AG, Do Egito ES. Trends in rheumatic fever: clinical aspects and perspectives in prophylactic treatments. Expert Opin Drug Deliv. 2012 Sep;9(9):1099-110.
[6]
Cuddy PG.Benzathine penicillin G in the treatment of neurosyphilis. Drug Intell Clin Pharm. 1982 Mar;16(3):205-10.
[7]
Taranta A, Gordis L. The prevention of rheumatic fever: opportunities, frustrations, and challenges. Cardiovasc Clin. 1972;4(3):1-10.
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