167869-21-8 PD 98059 AKSci X7398
 
 
Loading Please Wait...
  X7398    AKSci Reference Standard
PD 98059, 98% (HPLC)
 
2-(2-Amino-3-methoxyphenyl)-4H-chromen-4-one
IDENTITY
CAS Number:167869-21-8
MDL Number:MFCD00671789
MF:C16H13NO3
MW:267.28
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO =30mg/mL, Water <1.2mg/mL, Ethanol =2.6mg/mL
Application(s):Non-ATP competitive MEK inhibitor
Form:Free Base
Research Area:Cancer

REVIEW
 PD98059 is inhibitor of mitogen-activated protein kinase kinase (MAPKK / MEK). PD98059 acts by binding to the inactivated form of MEK, thereby preventing its phosphorylation by cRAF or MEK kinase (IC50 = 2-7 µM). PD98059 inhibits cell growth and proliferation in acute myelogenous leukemia (AML) cell lines; causes G1 arrest by blocking p53-dependent p21 induction.

REFERENCES
[1]Tsai CH, Lee SS, Huang FM, Chang YC.Regulation of protease-activated receptor-1 expression in human buccal fibroblasts stimulated with arecoline.Head Neck. 2012 Sep 10.
[2] Tang Y, Sun S, Jiang Y, Zheng C, Liu F.Knockdown of clusterin sensitizes pancreatic cancer cells to gemcitabine chemotherapy by ERK1/2 inactivation.J Exp Clin Cancer Res. 2012 Sep 11;31(1):73.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of April 24, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Chemotherapeutics


PubChem