918505-84-7 PLX-4720 AKSci X7406
 
 
Loading Please Wait...
  X7406    
PLX-4720, 98% (HPLC)
 
N-(3-(5-Chloro-1H-pyrrolo[2,3-b]ipyridine-3-carbonyl)-2,4-difluorophenyl)propane-1-sulfonamide
IDENTITY
CAS Number:918505-84-7
MDL Number:MFCD14635203
MF:C17H14ClF2N3O3S
MW:413.83
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:210-220°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 83mg/mL, Water <1mg/mL, Ethanol <1mg/mL
Application(s):Inhibitor of B-Raf and c-Raf
Form:Free base

REVIEW
 PLX-4720 is a B-raf inhibitor with IC50 of 160 nM.

REFERENCES
[1]Oikonomou E, Koc M, Sourkova V, Andera L, Pintzas A.Selective BRAFV600E inhibitor PLX4720, requires TRAIL assistance to overcome oncogenic PIK3CA resistance.PLoS One. 2011;6(6):e21632. Epub 2011 Jun 27.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 20, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives >


PubChem