382180-17-8 Pyroxamide AKSci Y0215
 
 
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  Y0215    AKSci Reference Standard
Pyroxamide, 98% (HPLC)
 
n-Hydroxy-n'-(pyridin-3-yl)octanediamide
IDENTITY
CAS Number:382180-17-8
MDL Number:MFCD13194970
MF:C13H19N3O3
MW:265.31
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):HDAC
Form:Free acid
Research Area:Cancer

REVIEW
 Pyroxamide is an inhibitor of HDAC1. It induces apoptosis and cell cycle arrest in leukemia, bladder and prostate cancer cell lines.

REFERENCES
[1]Remiszewski, Stacy W.; Sambucetti, Lidia C.; Atadja, Peter; Bair, Kenneth W.; Cornell, Wendy D.; Green, Michael A.; Howell, Kobporn Lulu; Jung, Manfred; Kwon, Paul; Trogani, Nancy; et al Inhibitors of Human Histone Deacetylase: Synthesis and Enzyme and Cellular Activity of Straight Chain Hydroxamates Journal of Medicinal Chemistry (2002), 45(4), 753-757.
[2] Butler LM, Webb Y, Agus DB, Higgins B, Tolentino TR, Kutko MC, LaQuaglia MP, Drobnjak M, Cordon-Cardo C, Scher HI, Breslow R, Richon VM, Rifkind RA, Marks PA.Inhibition of transformed cell growth and induction of cellular differentiation by pyroxamide, an inhibitor of histone deacetylase. Clin Cancer Res. 2001 Apr;7(4):962-70.
[3] Kouraklis G, Theocharis S.Histone deacetylase inhibitors and anticancer therapy. Curr Med Chem Anticancer Agents. 2002 Jul;2(4):477-84.
[4] Bradner JE, West N, Grachan ML, Greenberg EF, Haggarty SJ, Warnow T, Mazitschek R. Chemical phylogenetics of histone deacetylases. Nat Chem Biol. 2010 Mar;6(3):238-243.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of April 20, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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