327036-89-5 TDZD-8 AKSci Y0470
 
 
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  Y0470    
TDZD-8, 98% (HPLC)
 
4-Benzyl-2-methyl-1,2,4-thiadiazolidine-3,5-dione
IDENTITY
CAS Number:327036-89-5
MDL Number:MFCD04973552
MF:C10H10N2O2S
MW:222.26
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:60-65°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >10mg/mL
Application(s):A thiadiazolidinone analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3be

REVIEW
 GSK-3beta Inhibitor I is a thiadiazolidinone (TDZD) analog that acts as a highly selective, non-ATP competitive inhibitor of GSK-3beta (IC50 = 2 µM). GSK-3beta Inhibitor I inhibits PKC and Flt-3 activities (IC50 = 1.4-5.5 µM and 673 nM, respectively). GSK-3beta Inhibitor I does not significantly affect the activities of Cdk-1/cyclin B, CK-II, and PKA, (IC50 > 100 µM). This compound binds to the active site of GSK-3beta.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H334

Precautionary Statements
P261; P285; P304+P341; P342+P311; P501

Current as of April 18, 2024


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