27687-14-5 trans-Boc-tranexamic acid AKSci C285
 
 
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  C285    
trans-Boc-tranexamic acid
, 98% (GC)
 
trans-4-(Boc-aminomethyl)cyclohexanecarboxylic Acid




IDENTITY
CAS Number:27687-14-5
MDL Number:MFCD00673773
MF:C13H23NO4
MW:257.33
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (GC)
Physical Form (at 20°C):Solid
Melting Point:135-138°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW

 Boc-tranexamic acid is a key intermediate in the preparation of tranexamic acid and is also used in the preparation of inhibitors of various enzymes and receptors.

REFERENCES
[1]Oguro, Katsunori; Nojima, Hiroshi; Hashizume, Nobuyuki; Ohno, Norio; Naito, Taketoshi Antiulcer compositions containing N-benzoyl- and N-cyclohexylcarbonyl-L-phenylalanine derivatives Eur. Pat. Appl. (1989), EP 317959 A2 19890531.
[2] Andrzej, Roman Batt; Baxter, Andrew John; Heeney, Celine; Stockley, Martin Lee; Bryan Roe, Michael; Hudson, Peter; Handy, Rachel Preparation of tetraaza-benzo[f]azulenes as vasopressin V1a antagonists PCT Int. Appl. (2006), WO 2006021213 A2 20060302.
[3] Bock, Mark G.; Evans, Ben E.; Hobbs, Doug W.; Williams, Peter D.; Anderson, Paul S.; Freidinger, Roger M.; Pettibone, Douglas J. Benzoxazinone and benzopyrimidinone piperidinyl tocolytic oxytocin receptor antagonists PCT Int. Appl. (1995), WO 9502405 A1 19950126.
[4] Katano, Kiyoaki; Shitara, Eiki; Shimizu, Masaro; Sasaki, Kazue; Miura, Tomoaki; Isomura, Yasuko; Kawaguchi, Mami; Ohuchi, Shokichi; Tsuruoka, Takashi Tetrahydrothienopyridine derivatives as novel GPIIb/IIIa antagonists Bioorganic & Medicinal Chemistry Letters (1996), 6(21), 2601-2606.
[5] Rueger, Heinrich; Schmidlin, Tibur; Rigollier, Pascal; Yamaguchi, Yasuchika; Tintelnot-Blomley, Marina; Schilling, Walter; Criscione, Leoluca; Mah, Robert Preparation of 2-aminoquinazolines as neuropeptide Y subtype Y5 receptor antagonists. PCT Int. Appl. (1997), WO 9720823 A2 19970612.
[6] Geyer, Andrew G.; McClellan, William J.; Rockway, Todd W.; Stewart, Kent D.; Weitzberg, Moshe; Wendt, Michael D. Preparation of naphthalenecarboximidamides as urokinase inhibitors PCT Int. Appl. (1999), WO 9905096 A2 19990204.
[7] Marzabadi, Mohammad R.; Wong, Wai C.; Noble, Stewart A.; Desai, Mahesh N. Preparation of triazinamines, thiazolamines, and benzo[2,3]thiepino[4,5-d][1,3]thiazol-2-ylamines as selective NPY (Y5) antagonists PCT Int. Appl. (2000), WO 2000064880 A1 20001102.
[8] Lagu, Bharat; Wetzel, John; Marzabadi, Mohammad R.; Deleon, John E.; Gluchowski, Charles; Noble, Stewart; Nagarathnam, Dhanapalan; Chiu, George Preparation and use of arylpyrimidines as selective melanin concentrating hormone-1 (mch-1) receptor antagonists PCT Int. Appl. (2002), WO 2002006245 A1 20020124.
[9] Baer, Thomas; Martin, Thomas; Stadlwieser, Josef; Wollin, Stefan-Lutz; Zech, Karl; Sommerhoff, Christian P.; Ulrich, Wolf-Ruediger Preparation of N,N'-bis(N-alkanoyl-2-alkoxycarbonyl-4-pyrrolidinyl)-2,6-dioxoperhydro-1,5-diazocine-1,5-diacetamides and analogs as tryptase inhibitors PCT Int. Appl. (2002), WO 2002060895 A1 20020808.
[10] Wellington K, Wagstaff AJ. Tranexamic acid: a review of its use in the management of menorrhagia. Drugs. 2003;63(13):1417-33.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501


Current as of May 10, 2024


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CATEGORIES

 Amino Acids > Unnatural Amino Acids, Boc Amino Acids
 APIs and Bioactives > Antihemorrhagics
 APIs and Bioactives > Antihemorrhagics


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