2068-78-2 Vincristine sulfate salt AKSci E375
 
 
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  E375    
Vincristine sulfate salt, 95% (HPLC)
 



IDENTITY
CAS Number:2068-78-2
MDL Number:MFCD08706469
MF:C46H56N4O10.H2SO4
MW:923.36
EINECS:218-190-0
BRN:3924631
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>300°C
Boiling Point:273-281°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:II
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 100mg/mL; H2O: 60mg/mL; EtOH: <1mg/mL; MeOH: 20mg/mL
Application(s):Microtubule function inhibitor
Form:Sulfate salt

REVIEW
 Vincristine Sulfate is a kind of microtubule function inhibitor with IC50 of 10.4±1.1, 28.1±3.4, 22.4±2.1 µM for HL-60, Bel7402, HO-8910, respectively. It is the sulfate salt of a natural alkaloid isolated from the plant Vinca rosea Linn with antimitotic and antineoplastic activities. Vincristine binds irreversibly to microtubules and spindle proteins in S phase of the cell cycle and interferes with the formation of the mitotic spindle, thereby arresting tumor cells in metaphase. The IC50 and IC90 of vincristine for the 4 vaccine-associated feline sarcoma (VAFS) cell lines were between 0.005 to 0.039 µg/ml and 0.045 to 1.027 µg/ml, respectively .This agent also depolymerizes microtubules and may also interfere with amino acid, cyclic AMP, and glutathione metabolism.

REFERENCES
[1]Qweider, M.; Gilsbach, J. M.; Rohde, V. (2007). Inadvertent Intrathecal Vincristine Administration: A Neurosurgical Emergency. Case Report. Journal of Neurosurgery: Spine 6 (3): 280-283. PMID 17355029.
[2] Graf, W. D.; Chance, P. F.; Lensch, M. W.; Eng, L. J.; Lipe, H. P.; Bird, T. D. (1996). Severe Vincristine Neuropathy in Charcot-Marie-Tooth Disease Type 1A. Cancer 77 (7): 1356-1362. PMID 8608515.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H300; H341; H361

Precautionary Statements
P201; P202; P264; P270; P281; P301+P310; P308+P313; P321; P330; P405; P501

Current as of May 10, 2024


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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WARNING: Attention California residents: This product can expose you to chemicals including Vincristine sulfate salt, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Alkaloids, Chemotherapeutics


PubChem