121032-29-9 Nelarabine AKSci J10096
 
 
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  J10096    AKSci Reference Standard
Nelarabine, 98%
 
Arranon
IDENTITY
CAS Number:121032-29-9
MDL Number:MFCD00871078
MF:C11H15N5O5
MW:297.27
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:127-130°C
Optical Rotation:+55.9° (c=0.27, DMF)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 60mg/mL; H2O: 3mg/mL; EtOH: <1mg/mL
Application(s):DNA synthesis and cytotoxicity inhibitor
Form:Free Base

REVIEW
 Nelarabine is a purine nucleoside-based chemotherapy drug used in T-cell acute lymphoblastic leukemia. It is converted to its corresponding arabinosylguanine nucleotide triphosphate (araGTP), resulting in inhibition of DNA synthesis and cytotoxicity.

REFERENCES
[1]Dunsmore KP, Devidas M, Linda SB, Borowitz MJ, Winick N, Hunger SP, Carroll WL, Camitta BM (2012). Pilot study of nelarabine in combination with intensive chemotherapy in high-risk T-cell acute lymphoblastic leukemia: a report from the Children's Oncology Group. J Clin Oncol. 30(22):2753-9. PMID 22734022.
[2] Krenitsky, Thomas Anthony; Koszalka, George Walter; Jones, Lynda Addington; Averett, Devron Randolph; Moorman, Allan Ray Preparation and testing of purine arabinosides as antiviral agents Eur. Pat. Appl. (1988), EP 294114 A2 19881207.
[3] Averett, Devron R.; Koszalka, George W.; Fyfe, James A.; Roberts, Grace B.; Purifoy, Dorothy J. M.; Krenitsky, Thomas A. 6-Methoxypurine arabinoside as a selective and potent inhibitor of varicella-zoster virus Antimicrobial Agents and Chemotherapy (1991), 35(5), 851-7.
[4] Kisor DF.Nelarabine: a nucleoside analog with efficacy in T-cell and other leukemias. Ann Pharmacother. 2005 Jun;39(6):1056-63.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 10, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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