58-32-2 Dipyridamole AKSci J10379
 
 
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  J10379    AKSci Reference Standard
Dipyridamole, >98% (HPLC), powder
 
2,6-Bis(diethanolamine)-4,8-dipiperidinopyrimido[5,4-d]pyrimidine
Persantin
Permole
IDENTITY
CAS Number:58-32-2
MDL Number:MFCD00010555
MF:C24H40N8O4
MW:504.63
EINECS:200-374-7
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:165-167°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 101mg/mL; H2O: <1mg/mL; EtOH: 50mg/mL
Application(s):Phosphodiesterase Inhibitor; Platelet Aggregation Inhibitor
Form:Free Base

REVIEW
 Dipyridamole likely inhibits both adenosine deaminase and phosphodiesterase, preventing the degradation of cAMP, an inhibitor of platelet function. This elevation in cAMP blocks the release of arachidonic acid from membrane phospholipids and reduces thromboxane A2 activity. Dipyridamole also directly stimulates the release of prostacyclin, which induces adenylate cyclase activity, thereby raising the intraplatelet concentration of cAMP and further inhibiting platelet aggregation.

REFERENCES
[1]Diener HC, Cunha L, Forbes C, Sivenius J, Smets P, Lowenthal A: European Stroke Prevention Study. 2. Dipyridamole and acetylsalicylic acid in the secondary prevention of stroke. J Neurol Sci. 1996 Nov;143(1-2):1-13.
[2] Onoue S, Inoue R, Taniguchi C, Kawabata Y, Yamashita K, Wada K, Yamauchi Y, Yamada S (2012). Improved dissolution and pharmacokinetic behavior of dipyridamole formulation with microenvironmental pH-modifier under hypochlorhydria. Int J Pharm. 426(1-2):61-6. PMID 22266536.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 10, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antiplatelets, Thrombosis


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