REVIEW Ranitidine (Zantac) is a histamine H2-receptor antagonist with IC50 of 3.3 ± 1.4 µM. It inhibits stomach acid production. It is also used alongside fexofenadine and other antihistamines for the treatment of skin conditions such as hives. It has 10% the affinity that cimetidine has to CYP450 so it causes fewer side effects, but other H2 blockers famotidine and nizatidine have no CYP450 significant interactions.
REFERENCES
[1]
Jakob SM, Parviainen I, Ruokonen E, et al. (2005). Lack of effect of ranitidine on gastric luminal pH and mucosal PCO2 during the first day in the ICU. Acta Anaesthesiol Scand 49 (3): 390-396.
[2]
US patent US4128658, Aminoalkyl furan derivatives, 1978
[3]
Pali-Schöll I, Jensen-Jarolim E (April 2011). Anti-acid medication as a risk factor for food allergy. Allergy 66 (4): 469-77. doi:10.1111/j.1398-9995.
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