17321-77-6 Clomipramine HCl AKSci J10410
 
 
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  J10410    AKSci Reference Standard
Clomipramine HCl, 99% (HPLC), powder
 
3-Chloro-10,11-dihydro-N,N-dimethyl-5H-dibenz[b,f]azepine-5-propanamine hydrochloride
Anafranil hydrochloride
IDENTITY
CAS Number:17321-77-6
MDL Number:MFCD00069234
MF:C19H24Cl2N2
MW:351.31
EINECS:241-344-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:194-196°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 70mg/mL; H2O: 25mg/mL; EtOH: 70mg/mL 0.1M HCl
Application(s):Serotonin transporter (SERT); Norepinephrine transporter (NET); Dopamine transporter (DAT)
Form:HCl salt

REVIEW
 Clomipramine is a strong, but not completely selective serotonin reuptake inhibitor (SRI), as the active main metabolite desmethyclomipramine acts preferably as an inhibitor of noradrenaline reuptake. α1-receptor blockage and β-down-regulation have been noted and most likely play a role in the short term effects of clomipramine. A blockade of sodium-channels and NDMA-receptors might, as with other tricyclics, account for its effect in chronic pain, in particular the neuropathic type.

REFERENCES
[1]Albert U, Aguglia E, Maina G, Bogetto F (November 2002). Venlafaxine versus clomipramine in the treatment of obsessive-compulsive disorder: a preliminary single-blind, 12-week, controlled study. J Clin Psychiatry 63 (11): 1004-9. PMID 12444814.
[2] Greist, JH (Jan 1995). Efficacy and tolerability of serotonin transport inhibitors in obsessive-compulsive disorder. A meta-analysis. Archives of General Psychiatry. 52 1 (1): 53-60. PMID 7811162.
[3] Millan MJ, Gobert A, Lejeune F, et al. (August 2001). S33005, a novel ligand at both serotonin and norepinephrine transporters: I. Receptor binding, electrophysiological, and neurochemical profile in comparison with venlafaxine, reboxetine, citalopram, and clomipramine. The Journal of Pharmacology and Experimental Therapeutics 298 (2): 565-80. PMID 11454918
[4] Monsma FJ, Shen Y, Ward RP, Hamblin MW, Sibley DR (March 1993). Cloning and expression of a novel serotonin receptor with high affinity for tricyclic psychotropic drugs. Molecular Pharmacology 43 (3): 320-7. PMID 7680751.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P322; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 10, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Dopamine Antagonists, Antidepressants


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