REVIEW Vincamine is a monoterpenoid indole alkaloid found in the leaves of Vinca minor, comprising about 25-65% of the indole alkaloids found in Vinca minor by weight. It is also found in the species Catharanthus roseus. Vincamine is poorly soluble potent neuroprotector and cerebral vasodilator, used for the treatment for CNS disorders. The compound is a peripheral vasodilator that increases blood flow to the brain (sold under the trademark Oxybral SR) . Generic drugs containing vincamine exist in specific regions. Most common drug preparations are in the sustained release forms. Vincamine is often used as a nootropic or agent to combat the effects of aging (also called smart drugs, memory enhancers, neuro enhancers, cognitive enhancers, and intelligence enhancers,), or in conjunction with other nootropics (such as piracetam) for a variety of purposes. Vincamine has been shown to be a potent blockers of voltage-gated Na+ channels, a mechanism that may contribute at least in part to the pharmacological/therapeutic benefit of these drugs.
REFERENCES
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Vereczkey L. Pharmacokinetics and metabolism of vincamine and related compounds. Eur J Drug Metab Pharmacokinet. 1985 Apr-Jun;10(2):89-103.
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Spagnoli A, Tognoni G. 'Cerebroactive' drugs. Clinical pharmacology and therapeutic role in cerebrovascular disorders. 1983 Jul;26(1):44-69.
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Erdo SA, Molnár P, Lakics V, Bence JZ, Tömösközi Z. Vincamine and vincanol are potent blockers of voltage-gated Na+ channels. Eur J Pharmacol. 1996 Oct 24;314(1-2):69-73.
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Fischhof PK, Möslinger-Gehmayr R, Herrmann WM, Friedmann A, Russmann DL, Therapeutic efficacy of vincamine in dementia. Neuropsychobiology. 1996;34(1):29-35.
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