57-41-0 Phenytoin AKSci J10494
 
 
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  J10494    AKSci Reference Standard
Phenytoin, 99% (HPPC)
 
5,5-Diphenylhydantoin
Lepitoin
IDENTITY
CAS Number:57-41-0
MDL Number:MFCD00005264
MF:C15H12N2O2
MW:252.27
EINECS:200-328-6
BRN:384532
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPPC)
Physical Form (at 20°C):Solid
Melting Point:293-298°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 51mg/mL; H2O: <1mg/mL; EtOH: 15mg/mL
Application(s):Inactive voltage-gated sodium channel stabilizer
Form:Free Base

REVIEW
 Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.

REFERENCES
[1]Maeda T, Sano N, Togei K, Shibata M, Izumi K, Otsuka H (1988). Lack of carcinogenicity of phenytoin in (C57BL/6 x C3H)F1 mice. Journal of Toxicology and Environmental Health 24 (1): 111-119. doi:10.1080/15287398809531144. PMID 3373561.
[2] Arya R, Gulati S, Kabra M, Sahu JK, Kalra V (2011). Folic acid supplementation prevents phenytoin-induced gingival overgrowth in children. Neurology 76 (15): 1338-1343. doi:10.1212/WNL.0b013e3182152844. PMC 3090066. PMID 21482950.
[3] Scheinfeld N (2003). Phenytoin in Cutaneous Medicine: Its Uses, Mechanisms and Side Effects. Dermatology Online Journal 9 (3): 6. PMID 12952753.
[4] Man CB, Kwan P, Baum L, et al. (2007). Association between HLA-B*1502 allele and antiepileptic drug-induced cutaneous reactions in Han Chinese. Epilepsia 48 (5): 1015-1018. doi:10.1111/j.1528-1167.2007.01022.x. PMID 17509004.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H350; H360

Precautionary Statements
P201; P202; P264; P270; P281; P301+P312; P308+P313; P330; P405; P501

Current as of May 10, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Phenytoin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Anticonvulsants, Arrhythmia


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