2-[(2,6-Dichlorophenyl)amino]benzeneacetic acid sodium salt
IDENTITY
CAS Number:
15307-79-6
MDL Number:
MFCD00082251
MF:
C14H10Cl2NNaO2
MW:
318.13
EINECS:
239-346-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
99% (HPLC), powder
Physical Form (at 20°C):
Solid
Melting Point:
279-289°C
Long-Term Storage:
Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:
UN2811
Hazard Class:
6.1; Poison
Packing Group:
III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.
BIOLOGICAL INFO
Solubility:
H2O: 50mg/mL
Application(s):
Non-selective COX inhibitor
Form:
Sodium Salt
REVIEW The antiinflammatory effects of diclofenac are believed to be due to inhibition of both leukocyte migration and the enzyme cylooxygenase (COX-1 and COX-2), leading to the peripheral inhibition of prostaglandin synthesis. As prostaglandins sensitize pain receptors, inhibition of their synthesis is responsible for the analgesic effects of diclofenac. Antipyretic effects may be due to action on the hypothalamus, resulting in peripheral dilation, increased cutaneous blood flow, and subsequent heat dissipation.
REFERENCES
[1]
Kearney PM, Baigent C, Godwin J, Halls H, Emberson JR, Patrono C: Do selective cyclo-oxygenase-2 inhibitors and traditional non-steroidal anti-inflammatory drugs increase the risk of atherothrombosis? Meta-analysis of randomised trials. BMJ. 2006 Jun 3;332(7553):1302-8.
[2]
Solomon DH, Avorn J, Sturmer T, Glynn RJ, Mogun H, Schneeweiss S: Cardiovascular outcomes in new users of coxibs and nonsteroidal antiinflammatory drugs: high-risk subgroups and time course of risk. Arthritis Rheum. 2006 May;54(5):1378-89.
[3]
FitzGerald GA, Patrono C: The coxibs, selective inhibitors of cyclooxygenase-2. N Engl J Med. 2001 Aug 9;345(6):433-42.
[4]
Graham DJ: COX-2 inhibitors, other NSAIDs, and cardiovascular risk: the seduction of common sense. JAMA. 2006 Oct 4;296(13):1653-6. Epub 2006 Sep 12.
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