147-24-0 Diphenhydramine hydrochloride AKSci J10649
 
 
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  J10649    
Diphenhydramine hydrochloride, >98% (HPLC), powder
 
Benzhydramine hydrochloride
IDENTITY
CAS Number:147-24-0
MDL Number:MFCD00012479
MF:C17H21NO.HCl
MW:291.82
EINECS:205-687-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:168-174°C
Long-Term Storage:Store long-term in a cool, dry place
Note:Manual review is required before order is released.
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 58mg/mL; H2O: 50mg/mL; EtOH: 58mg/mL
Application(s):Histamine H1 antagonist
Form:HCl Salt

REVIEW
 A first-generation antihistamine possessing anticholinergic, antitussive, antiemetic and sedative properties which is mainly used to treat allergies. Diphenhydramine is an inverse agonist of the histamine H1 receptor. By blocking histamine in the capillaries it can reduce the intensity of allergic symptoms.

REFERENCES
[1]Unno K, Ozaki T, Mohammad S, Tsuno S, Ikeda-Sagara M, Honda K, Ikeda M (2012). First and second generation H1 histamine receptor antagonists produce different sleep-inducing profiles in rats. Eur J Pharmacol. 683(1-3):179-85. PMID 22449385.
[2] Gevins A, McEvoy LK, Smith ME, Chan CS, Sam-Vargas L, Baum C, Ilan AB (2012). Long-term and within-day variability of working memory performance and EEG in individuals. Clin Neurophysiol. 123(7):1291-9. PMID 22154302.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of May 10, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Antihistamines


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