63610-08-2 Indobufen AKSci J54144
 
 
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  J54144    
Indobufen, 95%
 
4-(1,3-Dihydro-1-oxo-2H-isoindol-2-yl)-α-ethylbenzeneacetic Acid
1-Oxo-2-[p-[(α-ethyl)carboxymethyl]phenyl]isoindoline
2-[p-(1-Oxo-2-isoindolinyl)phenyl]butyric Acid
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IDENTITY
CAS Number:63610-08-2
MDL Number:MFCD00572250
MF:C18H17NO3
MW:295.33
EINECS:264-364-4
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:182-188°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Platelet aggregation inhibitor

REVIEW
 Indobufen, an isoindolinyl phenyl-butyric acid derivative, reversibly inhibits platelet aggregation in vitro and ex vivo at the level of platelet cyclo-oxygenase, thereby suppressing production of thromboxane, a potent platelet activator.

REFERENCES
[1]Giraldi, Pier Nicola; Nannini, Giuliano; Logemann, Willy; Tommasini, Raffaele; Buttinoni, Ada; Biasoli, Giovanni Analgesic and antiinflammatory 1-isoindolinone derivatives Ger. Offen. (1972), DE 2154525 A 19720615.
[2] Nannini, G.; Giraldi, P. N.; Molgora, G.; Biasoli, G.; Spinelli, F.; Logemann, W.; Dradi, E.; Zanni, G.; Buttinoni, A.; Tommasini, R. New analgesic-antiinflammatory drugs. 1-Oxo-2-substituted isoindoline derivatives Arzneimittel-Forschung (1973), 23(8), 1090-100.
[3] Bergamaschi, M.; Ceserani, R.; Pierucci, L.; Pogliani, E.; Spelta, A. Indobufen, a new inhibitor of platelet aggregation. Studies in guinea pigs Pharmacological Research Communications (1979), 11(3), 279-94.
[4] Vinazzer H; Fuccella L M Clinical pharmacology studies with indobufen (K 3920): inhibitor of platelet aggregation Journal of clinical pharmacology (1980), 20(5-6 Pt 1), 316-25.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 9, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Antiplatelets, Thrombosis


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