REVIEW 5-Aminolevulinic acid hydrochloride is used as a photosensitizer for photodynamic detection and therapy for actinic keratosis. It is biosynthesized from succinyl-CoA and glycine and is the first compound in the porphyrin synthesis pathway. It elicits synthesis and accumulation of fluorescent porphyrins in epithelia and neoplastic tissues.
REFERENCES
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Herdeis, Claus; Dimmerling, Anna A three-step synthesis of epsilon-aminolevulinic acid Archiv der Pharmazie (Weinheim, Germany) (1984), 317(4), 304-6.
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Kawakami, Hiroshi; Ebata, Takashi; Matsushita, Hajime A new synthesis of 5-aminolevulinic acid Agricultural and Biological Chemistry (1991), 55(6), 1687-8.
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Matsumura, Yoshihiro; Takeshima, Yo-ichiro; Okita, Hideki A convenient method for introducing oxo group into the beta-position of cyclic amines and its application to synthesis of epsilon-aminolevulinic acid Bulletin of the Chemical Society of Japan (1994), 67(1), 304-6.
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Nokes B, Apel M, Jones C, Brown G, Lang JE.Aminolevulinic acid (ALA): photodynamic detection and potential therapeutic applications.J Surg Res. 2013 May;181(2):262-71.
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