146665-77-2 Eptaplatin AKSci N771
 
 
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  N771    AKSci Reference Standard
Eptaplatin, 98%
 



IDENTITY
CAS Number:146665-77-2
MDL Number:MFCD00931412
MF:C8H18N2O2.C3H2O4Pt
MW:471.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:284-290°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):A platinum-based coordination compound

REVIEW
 Eptaplatin is a water-soluble, platinum-based alkylating agent derived from cisplatin. Preclinical studies suggest that it may have greater antitumor activity and lower toxicity than cisplatin. It has been found to be embryotoxic at a minimally maternally toxic dose in rats.

REFERENCES
[1]Liu Weiping; Chen Xizhu; Ye Qingsong; Xu Yongping; Xie Chengying; Xie Mingjin; Chang Qiaowen; Lou Liguang A novel water-soluble heptaplatin analogue with improved antitumor activity and reduced toxicity Inorganic chemistry (2011), 50(12), 5324-6.
[2] Kim, Dae-Kee; Kim, Ganghyeok; Gam, Jongsik; Cho, Yong-Baik; Kim, Hun-Taek; Tai, Joo-Ho; Kim, Key H.; Hong, Weon-Seon; Park, Jae-Gahb Synthesis and Antitumor Activity of a Series of [2-Substituted-4,5-bis(aminomethyl)-1,3-Dioxolane]platinum(II) Complexes Journal of Medicinal Chemistry (1994), 37(10), 1471-85.
[3] Kim DK, Ahn JS, Ryu G, Kim KH, Park CW, Kim MS, Chung MH, Shin SG, Suh YH, Kim YS General pharmacology of cis-malonato[4R,5R)-4,5-bis-(aminomethyl)-2-isopropyl-1,3- dioxolane]platinum(II). Arzneimittelforschung. 1994 Sep;44(9):1080-8.
[4] Hong WS, Kim HT, Kim KH, Kim DK.In vitro antitumor activity of a new platinum complex, cis-malonato [(4R,5R)-4,5-bis(aminomethyl)-2-isopropyl-1,3-dioxolane] platinum (II) (SKI 2053R), against human lung and stomach cancer cell lines.Anticancer Res. 1995 Jan-Feb;15(1):51-4.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 10, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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