189224-26-8 Ozagrel sodium AKSci E303
 
 
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  E303    
Ozagrel sodium, 98% (HPLC)
 
Sodium ozagrel
Cataclot
Xanbon
IDENTITY
CAS Number:189224-26-8
MDL Number:MFCD00875845
MF:C13H11N2NaO2
MW:250.23
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>300°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Enzyme Inhibitor; Fibrinolytic Agent; Histamine Antagonist; Selective thromboxane A2 synthetase inh
Form:Sodium salt

REVIEW
 Ozagrel sodium is an antiplatelet agent and thromboxane A2 (TXA2) synthetase inhibitor. TXA2 acts as a vasoconstrictor and platelet aggregator in brain ischemia. Ozagrel sodium reduces hyperperfusion and cerebral edema by restricting the generation of TXA2 while facilitating the generation of prostacyclin. Due to this mechanism, it has neuroprotective properties and has been shown to be effective for motor recovery in animal models of cerebral ischemia. It is now used for the treatment of acute thrombotic cerebral infarction or disturbance on motor functions.

REFERENCES
[1]Liang, Hongping Ozagrel sodium compound, preparation method and pharmaceutical composition thereof Faming Zhuanli Shenqing (2013), CN 103232395 A 20130807.
[2] Uyama O, Nagatsuka K, Nakabayashi S, Isaka Y, Yoneda S, Kimura K, Abe H. The effect of a thromboxane synthetase inhibitor, OKY-046, on urinary excretion of immunoreactive thromboxane B2 and 6-keto-prostaglandin F1 alpha in patients with ischemic cerebrovascular disease. Stroke. 1985 Mar-Apr;16(2):241-4.
[3] Ishitsuka Y, Moriuchi H, Isohama Y, Tokunaga H, Hatamoto K, Kurita S, Irikura M, Iyama K, Irie T (2009). A selective thromboxane A2 (TXA2) synthase inhibitor, ozagrel, attenuates lung injury and decreases monocyte chemoattractant protein-1 and interleukin-8 mRNA expression in oleic acid-induced lung injury in guinea pigs. J Pharmacol Sci. 111(2):211-5. PMID 19783866.
[4] Carter PR, McElhatten RM, Zhang S, Wright WS, Harris NR (2011). Thromboxane-prostanoid receptor expression and antagonism in dextran-sodium sulfate-induced colitis. Inflamm Res. 60(1):87-92. PMID 20694740.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
E303Ozagrel sodium

Current as of May 10, 2024


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⚠️
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CATEGORIES
 APIs and Bioactives > Antiplatelets, Thrombosis


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