66619 Vorinostat - AK Scientific
 
 
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  Catalog ID # 66619
Vorinostat
, 98% (HPLC)
 
N-hydroxy-N'-phenyl-octanediamide
Suberoylanilide hydroxamic acid
SAHA




IDENTITY
CAS Registry #:[149647-78-9]
MDL Number:MFCD00945317
MF:C14H20N2O3
MW:264.323
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Available Spectra:HPLC, LCMS
Physical Form:White to off-white crystalline powder
Melting Point:159-168°C
Long-Term Storage:Store at -20°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:DMSO: 53mg/mL; H2O: <1mg/mL; EtOH: 3mg/mL
Application(s):HDAC inhibitor
Form:Free Base

REVIEW

 Vorinostat inhibits the enzymatic activity of histone deacetylases HDAC1, HDAC2 and HDAC3 (Class I) and HDAC6 (Class II) at nanomolar concentrations (IC50< 86 nM). These enzymes catalyze the removal of acetyl groups from the lysine residues of histones proteins. In some cancer cells, there is an overexpression of HDACs, or an aberrant recruitment of HDACs to oncogenic transcription factors causing hypoacetylation of core nucleosomal histones. By inhibiting histone deacetylase, vorinostat causes the accumulation of acetylated histones and induces cell cycle arrest and/or apoptosis of some transformed cells. The mechanism of the antineoplastic effect of vorinostat has not been fully characterized.

REFERENCES
[1]Munshi A, Tanaka T, Hobbs ML, Tucker SL, Richon VM, Meyn RE: Vorinostat, a histone deacetylase inhibitor, enhances the response of human tumor cells to ionizing radiation through prolongation of gamma-H2AX foci. Mol Cancer Ther. 2006 Aug;5(8):1967-74.

Risk Description(s)
R61:May cause harm to the unborn child.
R68:Possible risk of irreversible effects.

Safety Description(s)
S53:Avoid exposure - obtain special instructions before use.
S36/37:Wear suitable protective clothing and gloves.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CATEGORIES

 APIs and Bioactives > Chemotherapeutics

USEFUL LINKS

  PubChem