30751-05-4 Troxipide AKSci E686
 
 
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  E686    
Troxipide, 98% (HPLC)
 
Troxipidum
Troxipida
3,4,5-Trimethoxy-N-(3-piperidyl)benzamide
IDENTITY
CAS Number:30751-05-4
MDL Number:MFCD00866876
MF:C15H22N2O4
MW:294.35
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:177-182°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Other solvents(Soluble): Methanol, Chloroform, Ethanol
Application(s):Anti-ulcer Agent; Anti-inflammatory Agent
Form:Free Base

REVIEW
 Troxipide is a drug used in the treatment of gastroesophageal reflux disease, the management of gastric ulcers, and amelioration of gastric mucosal lesions in acute gastritis and acute exacerbation of chronic gastritis. Troxipide is a novel systemic non-antisecretory gastric cytoprotective agent with anti-ulcer, anti-inflammatory and mucus secreting properties irrespective of pH of stomach or duodenum.

REFERENCES
[1]Kusugami K, Ina K, Hosokawa T, Kobayashi F, Kusajima H, Momo K, Nishio Y. Troxipide, a novel antiulcer compound, has inhibitory effects on human neutrophil migration and activation induced by various stimulants. Dig Liver Dis. (2000) 32(4): 305-11. PMID 11515628.
[2] Momo K, Hoshina K, Ishibashi Y, Saito T. Preventive effects of troxipide on a newly developed model of acute gastric mucosal lesion (AGML) induced by ischemia/reperfusion plus ammonia in the rat. Nihon Yakurigaku Zasshi. (1994) 104(4): 313-23. PMID 7959422.
[3] Dewan B, Balasubramanian A. Troxipide in the management of gastritis: a randomized comparative trial in general practice. Gastroenterol Res Pract. (2010) 2010: 758397. PMID 21127703.
[4] Irikura, Tsutomu; Kasuga, Kazunori; Segawa, Mitsuru Pharmaceutical N-[1-(aminobenzoyl)piperidyl]benzamides Ger. Offen. (1971), DE 1938512 A 19710114.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319

Precautionary Statements
P264; P280; P352; P332+P313; P362; P351; P338; P331; P337+P313;


Current as of April 26, 2024


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