70345 Vinblastine sulfate - AK Scientific
 
 
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  Catalog ID # 70345
Vinblastine sulfate
, 98%
 
Exal
Velban
Velbe
Vincaleukblastine sulfate




IDENTITY
CAS Registry #:[143-67-9]
MDL Number:MFCD08706468
MF:C46H58N4O9.H2SO4
MW:909.0526
EINECS:205-606-0
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to light yellow crystalline powder
Melting Point:267°C
Optical Rotation:-28 °(c=1.01, MeOH)
Long-Term Storage:Store long-term at -20°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:H2O: 10mg/mL;DMSO: 50mg/mL
Form:Sulfate salt

REVIEW

  Vinblastine is an antimicrotubule drug used to treat certain cancers. Vinblastine was traditionally obtained from the periwinkle plant Vinca rosea, in which it is biosynthesized by the joining of two alkaloids, catharanthine and vindoline. Vinblastine binds to tubulin and inhibits microtubule formation, resulting in disruption of mitotic spindle assembly and arrest of tumor cells in the M phase of the cell cycle.

REFERENCES
[1]Kuehne, M. E.; Matson, P. A.; Bornmann, W. G. Enantioselective Syntheses of Vinblastine, Leurosidine, Vincovaline, and 20'-epi-Vincovaline, Journal of Organic Chemistry 1991,56 (2): 513-528.
[2] Yokoshima, S; Tokuyama, H; Fukuyama, T. Total Synthesis of (+)-Vinblastine: Control of the Stereochemistry at C18' ". The Chemical Record 2009, 10 (2): 101-118.
[3] Houghton PJ, Houghton JA, Bowman LC, Hazelton BJ.Therapeutic selectivity of vinca alkaloids: a role for guanosine 5'-triphosphate Anticancer Drug Des. 1987 Oct;2(2):165-79.
[4] Navarro M, Bellmunt J, Bala?? C, Colomer R, Jolis L, del Campo JM Mitomycin-C and vinblastine in advanced breast cancer. Oncology. 1989;46(3):137-42.

Risk Description(s)
R22:Harmful if swallowed.
R37/38:Irritating to respiratory system and skin
R41:Risk of serious damage to the eyes.

Safety Description(s)
S26:In case of contact with eyes, rinse immediately with plenty of water and seek medical advice.
S36/39:Wear suitable protective clothing and eye/face protection.



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RELATED PRODUCTS
70345Vinblastine sulfate
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CATEGORIES

 APIs and Bioactives > Alkaloids, Chemotherapeutics

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