REVIEW Pipecurium bromide or Pipecuronium (Arduan) is a piperazinyl androstane derivative which is a non-depolarizing neuromuscular blocking agent (a nicotinic acetylcholine receptor antagonist) which acts as a muscle relaxant. Pipecurium bromide produces skeletal muscle paralysis by blocking neural transmission at the myoneural junction. The paralysis is selective initially and usually appears in the following muscles consecutively: levator muscles of eyelids, muscles of mastication, limb muscles, abdominal muscles, muscles of the glottis, and finally, the intercostal muscles and the diaphragm.
REFERENCES
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RK Mirakhur, Newer neuromuscular blocking drugs. An overview of their clinical pharmacology and therapeutic use. Drugs. 1992:44(2):182-99.
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PB Embree, Long-acting nondepolarizing neuromuscular blocking agents. AANA J. 1993;61(4):382-7.
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RK Mirakhur, New developments in nondepolarizing muscle relaxants. Yale J Biol Med. 1993;66(5):463-71.
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DR Bevan, Newer neuromuscular blocking agents. Pharmacol Toxicol. 1994;74(1):3-9.
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