H578 9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione - AK Scientific
 
 
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  Catalog ID # H578
9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione
, 98% (HPLC)
 



IDENTITY
CAS Registry #:[24916-90-3]
MDL Number:MFCD07782140
MF:C22H28O5
MW:372.4547
EINECS:246-529-2
SPECIFICATIONS & PROPERTIES
Purity:98% (HPLC)
Physical Form:White crystalline powder
Melting Point:230-235°C
Density:1.32
Shipping:Normal Temperature

BIOLOGICAL INFO
Solubility:Chloroform, DMSO, Methanol

REVIEW

 9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione is a key intermediate used in the synthesis of various biologically active corticosteroids, e.g. mometasone and furoate.

REFERENCES
[1]Fu, Xiaoyong; Tann, Chou-Hong; Thiruvengadam, T. K. Process Improvements in the Synthesis of Corticosteroid 9,11beta-Epoxides. Organic Process Research & Development. (2001) 5(4): 376-382.
[2] Li, Ping; Lu, Junrui; Li, Xia; Guo, Jianlong. Method for preparation of Mometasone furoate intermediate having hydroxy group at C21-position. Faming Zhuanli Shenqing Gongkai Shuomingshu. (2006) CN 1810825 A 20060802.
[3] Cherniak, Simon; Cyjon, Rosa; Ozer, Ilana; Nudelman, Igor. Process for the preparation of 17-desoxy-corticosteroids. PCT Int. Appl. (2012) WO 2012011106 A1 20120126.
[4] Steroids (1962), GB 912379 19621205
[5] Hirschmann, Ralph F.Fluoro hydroxy steroids (1962), US 3049556 19620814.
[6] Gerber, Herbert A. Hydrohalogenation of 9,11-epoxy steroids (1963), US 3086032 19630416.
[7] 9alpha-Halo steroids (1963), BE 634881 19631118
[8] VanRheenen, Verlan Henry; Huber, Joel Edward 16alpha-Methyl steroids Eur. Pat. Appl. (1985), EP 165037 A2 19851218.
[9] Kwok, Daw-iong Albert; Tsai, David J. S.; Tann, Chou-hong; Fu, Xiaoyong Process for the preparation of 17-esters of 9alpha,21-dihalo-pregnane-11beta,17alpha-diol-20-ones PCT Int. Appl. (1998), WO 9800437 A1 19980108.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem