24916-90-3 9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione AKSci H578
 
 
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  H578    
9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione, 98% (HPLC)
 



IDENTITY
CAS Number:24916-90-3
MDL Number:MFCD07782140
MF:C22H28O5
MW:372.45
EINECS:246-529-2
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:230-235°C
Density:1.32
Refractive Index:1.61
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Chloroform, DMSO, Methanol

REVIEW
 9,11b-Epoxy-17,21-dihydroxy-16a-methyl-9b-pregna-1,4-diene-3,20-dione is a key intermediate used in the synthesis of various biologically active corticosteroids, e.g. mometasone and furoate.

REFERENCES
[1]Fu, Xiaoyong; Tann, Chou-Hong; Thiruvengadam, T. K. Process Improvements in the Synthesis of Corticosteroid 9,11beta-Epoxides. Organic Process Research & Development. (2001) 5(4): 376-382.
[2] Li, Ping; Lu, Junrui; Li, Xia; Guo, Jianlong. Method for preparation of Mometasone furoate intermediate having hydroxy group at C21-position. Faming Zhuanli Shenqing Gongkai Shuomingshu. (2006) CN 1810825 A 20060802.
[3] Cherniak, Simon; Cyjon, Rosa; Ozer, Ilana; Nudelman, Igor. Process for the preparation of 17-desoxy-corticosteroids. PCT Int. Appl. (2012) WO 2012011106 A1 20120126.
[4] Steroids (1962), GB 912379 19621205

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 15, 2024


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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