15663-27-1 Cisplatin AKSci H878
 
 
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  H878    AKSci Reference Standard
Cisplatin, 99%, powder
 
cis-Diammineplatinum(II) dichloride
Cisplatinum
CDDP
more..
IDENTITY
CAS Number:15663-27-1
MDL Number:MFCD00011623
MF:H6Cl2N2Pt
MW:300.045
EINECS:239-733-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99%, powder
Physical Form (at 20°C):Solid
Melting Point:270°C (dec.)
Flash Point:Not applicable°C
Density:3.7
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN3288
Hazard Class:6.1; Poison
Packing Group:II
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Application(s):DNA Synthesis blocker
Form:Free Base

REVIEW
 Alkylating agents work by three different mechanisms: 1) attachment of alkyl groups to DNA bases, resulting in the DNA being fragmented by repair enzymes in their attempts to replace the alkylated bases, preventing DNA synthesis and RNA transcription from the affected DNA, 2) DNA damage via the formation of cross-links (bonds between atoms in the DNA) which prevents DNA from being separated for synthesis or transcription, and 3) the induction of mispairing of the nucleotides leading to mutations.

REFERENCES
[1]Tian H, Liu S, Zhang J, Zhang S, Cheng L, Li C, Zhang X, Dail L, Fan P, Dai L, Yan N, Wang R, Wei Y, Deng H (2012). Enhancement of cisplatin sensitivity in lung cancer xenografts by liposome-mediated delivery of the plasmid expressing small hairpin RNA targeting Survivin. J Biomed Nanotechnol. 8(4):633-41. PMID 22852473.
[2] Lee RX, Li QQ, Reed E (2012). beta-elemene effectively suppresses the growth and survival of both platinum-sensitive and -resistant ovarian tumor cells. Anticancer Res. 32(8):3103-13. PMID 22843880.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H300; H315; H317; H319; H334; H335; H350

Precautionary Statements
P201; P202; P261; P264; P270; P271; P272; P280; P285; P301+P310+P330; P302+P352; P304+P340+P312; P305+P351+P338; P308+P313; P333+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 26, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Cisplatin, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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