H927 Doxapram HCl - AK Scientific
 
 
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  Catalog ID # H927
Doxapram HCl
, 98%
 
3,3-Diphenyl-1-ethyl-4-(2-morpholinoethyl)-2-pyrrolidinone hydrochloride




IDENTITY
CAS Registry #:[7081-53-0]
MDL Number:MFCD00072148
MF:C24H30N2O2.HCl
MW:414.9681
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White powder
Melting Point:217-219 °C
Shipping:Normal Temperature

BIOLOGICAL INFO
Application(s):Central Nervous System Stimulant; Respiratory System Agent
Form:HCl salt

REVIEW

 A respiratory stimulant. Doxapram stimulates chemoreceptors in the carotid bodies of the carotid arteries, which in turn, stimulates the respiratory centre in the brain stem.

REFERENCES
[1]Meyer LC, Hetem RS, Fick LG, Mitchell D, Fuller A (2010). Effects of serotonin agonists and doxapram on respiratory depression and hypoxemia in etorphine-immobilized impala (Aepyceros melampus). J Wildl Dis. 46(2):514-24. PMID 20688644.
[2] Li GC, Zhang HT, Jiao YG, Wu ZH, Fang F, Cheng J (2010). Glial cells are involved in the exciting effects of doxapram on brainstem slices in vitro. Cell Mol Neurobiol. 30(5):667-70. PMID 20140700.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives

USEFUL LINKS

  @PubChem  @Wikipedia