50-02-2 Dexamethasone AKSci J10029
 
 
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  J10029    AKSci Reference Standard
Dexamethasone, 99% (HPLC)
 
11beta,16alpha)-9-Fluoro-11,17,21-trihydroxy-16-methylpregna-1,4-diene-3,20-dione
9alpha-Fluoro-16alpha-methyl-11beta,17alpha,21-trihydroxy-1,4-pregnadiene-3,20-dione
9alpha-Fluoro-16alpha-methylprednisolone
IDENTITY
CAS Number:50-02-2
MDL Number:MFCD00064136
MF:C22H29FO5
MW:392.46
EINECS:200-003-9
BRN:2066651
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:255-264°C
Optical Rotation:+72.0° - 80.0° (c=1, dioxane)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 79mg/mL; H2O: <1mg/mL; EtOH: 6mg/mL
Application(s):IL Receptor Inhibitor
Form:Free Base

REVIEW
 Dexamethasone is a glucocorticoid agonist. Unbound dexamethasone crosses cell membranes and binds with high affinity to specific cytoplasmic glucocorticoid receptors. This complex binds to DNA elements (glucocorticoid response elements) which results in a modification of transcription and, hence, protein synthesis in order to achieve inhibition of leukocyte infiltration at the site of inflammation, interference in the function of mediators of inflammatory response, suppression of humoral immune responses, and reduction in edema or scar tissue. The antiinflammatory actions of dexamethasone are thought to involve phospholipase A2 inhibitory proteins, lipocortins, which control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes.

REFERENCES
[1]Tewari-Singh N, Jain AK, Inturi S, Ammar DA, Agarwal C, Tyagi P, Kompella UB, Enzenauer RW, Petrash JM, Agarwal R (2012). Silibinin, dexamethasone, and doxycycline as potential therapeutic agents for treating vesicant-inflicted ocular injuries. Toxicol Appl Pharmacol. 264(1):23-31. PMIS 22841772.
[2] Heidari N, Miller AV, Hicks MA, Marking CB, Harada H (2012). Glucocorticoid-mediated BIM induction and apoptosis are regulated by Runx2 and c-Jun in leukemia cells. Cell Death Dis. 3:e349. PMID 22825467.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H315; H317; H319; H334; H335

Precautionary Statements
P261; P264; P271; P272; P280; P285; P302+P352; P304+P340; P305+P351+P338; P321; P333+P313; P337+P313; P342+P311; P362; P403+P233; P405; P501

RELATED PRODUCTS

Current as of April 27, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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