484-12-8 Osthol AKSci J10077
 
 
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  J10077    AKSci Reference Standard
Osthol, >98% (HPLC)
 
7-Methoxy-8-(3-methyl-2-buten-1-yl)-2H-chromen-2-one
IDENTITY
CAS Number:484-12-8
MDL Number:MFCD00076049
MF:C15H16O3
MW:244.29
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:85-88°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Methanol: 10 mg/mL
Application(s):Calcium channel blocker
Form:Free Base
Research Area:Endocrinology

REVIEW
 Osthol is an O-methylated coumarin, which is an active constituent of Cnidium monnieri, a traditional Chinese medicine used for its anti-inflammatory, analgesic, and anti-lipedemic activities. Pharmacologically , osthol is a calcium channel blocker. Recent studies indicate that osthole also suppresses fatty acid synthase expression in HER2-overexpressing breast cancer cells through modulating Akt/mTOR pathway, which indicates potential as a chemopreventive or chemotherapeutic agent for cancers that overexpress HER2.

REFERENCES
[1]JAMWAL KS, ANAND KK, CHOPRA IC. Pharmacological properties of a crystalline substance (Osthol) isolated from Prangos pabularia Lindl. Arch Int Pharmacodyn Ther. 1962 Aug 1;138:400-11.
[2] JAMWAL KS, SETHI OP, ANAND KK, CHOPRA IC. 7-METHOXY-8-ISO-PENTENYL COUMARIN (OSTHOL) -- TOXICITY AND ITS MECHANISM OF RESPIRATORY STIMULANT ACTION. Arch Int Pharmacodyn Ther. 1964 Aug 1;150:425-34.
[3] Chen ZC, Duan XB, Liu KR. The anti-allergic activity of osthol extracted from the fruits of Cnidium monnieri (L.) Cusson. Yao Xue Xue Bao. 1988 Feb;23(2):96-9.
[4] Li RZ, He YQ, Chiao M, Xu Y, Zhang QB, Meng JR, Gu Y, Ge LP. Studies of the active constituents of the Chinese drug duhuo Angelica pubescents. Yao Xue Xue Bao. 1989;24(7):546-51.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 30, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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