3778-73-2 Isophosphamide AKSci J10093
 
 
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  J10093    AKSci Reference Standard
Isophosphamide, 97% (GC)
 
Ifosfamide
Mitoxana
Ifex
more..
IDENTITY
CAS Number:3778-73-2
MDL Number:MFCD00057374
MF:C7H15Cl2N2O2P
MW:261.09
EINECS:223-237-3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:97% (GC)
Physical Form (at 20°C):Solid
Melting Point:39-42°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 52mg/mL; H2O: 52mg/mL; EtOH: 52mg/mL
Application(s):DNA Synthesis
Form:Free Base

REVIEW
 The exact mechanism of ifosfamide has not been determined, but appears to be similar to other alkylating agents. Ifosfamide requires biotransformation in the liver by mixed-function oxidases (cytochrome P450 system) before it becomes active. After metabolic activation, active metabolites of ifosfamide alkylate or bind with many intracellular molecular structures, including nucleic acids. The cytotoxic action is primarily through the alkylation of DNA, done by attaching the N-7 position of guanine to its reactive electrophilic groups. The formation of inter and intra strand cross-links in the DNA results in cell death.

REFERENCES
[1]Furlanut M, Franceschi L: Pharmacology of ifosfamide. Oncology. 2003;65 Suppl 2:2-6
[2] Fleming RA: An overview of cyclophosphamide and ifosfamide pharmacology. Pharmacotherapy. 1997 Sep-Oct;17(5 Pt 2):146S-154S.
[3] Wagner T: Ifosfamide clinical pharmacokinetics. Clin Pharmacokinet. 1994 Jun;26(6):439-56.
[4] Allen LM, Creaven PJ, Nelson RL: Studies on the human pharmacokinetics of isophosphamide (NSC-109724). Cancer Treat Rep. 1976 Apr;60(4):451-8.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301; H319

Precautionary Statements
P264; P270; P280; P301+P310; P305+P351+P338; P321; P330; P337+P313; P405; P501

Current as of April 26, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

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WARNING: Attention California residents: This product can expose you to chemicals including Isophosphamide, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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