57-83-0 Progesterone AKSci J10165
 
 
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  J10165    AKSci Reference Standard
Progesterone, >99% (HPLC), powder
 
4-Pregnene-3,20-dione
Prometrium
Agolutin
more..
IDENTITY
CAS Number:57-83-0
MDL Number:MFCD00003658
MF:C21H30O2
MW:314.46
EINECS:200-350-6
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:126-134°C
Optical Rotation:+179° - +185° (c=2, Dioxane)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 22mg/mL; H2O: <1mg/mL; EtOH: 63mg/mL
Application(s):Progesterone receptor; Mineralocorticoid receptor antagonist
Form:Free Base

REVIEW
 Progesterone shares the pharmacological actions of the progestins. Progesterone binds to the progesterone and estrogen receptors. Target cells include the female reproductive tract, the mammary gland, the hypothalamus, and the pituitary. Once bound to the receptor, progestins like Progesterone will slow the frequency of release of gonadotropin releasing hormone (GnRH) from the hypothalamus and blunt the pre-ovulatory LH (luteinizing hormone) surge. In women who have adequate endogenous estrogen, progesterone transforms a proliferative endometrium into a secretory one. Progesterone is essential for the development of decidual tissue and is necessary to increase endometrial receptivity for implantation of an embryo. Once an embryo has been implanted, progesterone acts to maintain the pregnancy. Progesterone also stimulates the growth of mammary alveolar tissue and relaxes uterine smooth muscle. It has little estrogenic and androgenic activity.

REFERENCES
[1]Allen WM: THE ISOLATION OF CRYSTALLINE PROGESTIN. Science. 1935 Aug 2;82(2118):89-93.
[2] Allen WM: Progesterone: how did the name originate? South Med J. 1970 Oct;63(10):1151-5.
[3] Schumacher M, Guennoun R, Robert F, Carelli C, Gago N, Ghoumari A, Gonzalez Deniselle MC, Gonzalez SL, Ibanez C, Labombarda F, Coirini H, Baulieu EE, De Nicola AF: Local synthesis and dual actions of progesterone in the nervous system: neuroprotection and myelination. Growth Horm IGF Res. 2004 Jun;14 Suppl A:S18-33.
[4] Hould FS, Fried GM, Fazekas AG, Tremblay S, Mersereau WA: Progesterone receptors regulate gallbladder motility. J Surg Res. 1988 Dec;45(6):505-12.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H351; H360; H362

Precautionary Statements
P201; P202; P281; P308+P313; P405; P501

Current as of May 13, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Progesterone, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Steroid Hormones


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