50-55-5 Reserpine AKSci J10192
 
 
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  J10192    
Reserpine, 99% (HPLC), powder
 
11,17-Dimethoxy-18-[(3,4,5-trimethoxybenzoyl)oxy]yohimban-16-carboxylic acid methyl ester
IDENTITY
CAS Number:50-55-5
MDL Number:MFCD00005091
MF:C33H40N2O9
MW:608.68
EINECS:200-047-9
BRN:102014
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:260-265°C
Optical Rotation:-126° (c=1, CHCl3)
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: 13mg/mL; H2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Vesicular monoamine transporter (VMAT) blocker; Adrenergic Uptake Inhibitor
Form:Free Base

REVIEW
 An indole alkaloid antipsychotic and antihypertensive drug that has been used for the control of high blood pressure and for the relief of psychotic symptoms. Reserpine irreversibly blocks the vesicular monoamine transporter (VMAT). This normally transports free norepinephrine, serotonin, and dopamine from the cytoplasm of the presynaptic nerve terminal into storage vesicles for subsequent release into the synaptic cleft (exocytosis). Unprotected neurotransmitters are metabolized by MAO (as well as by COMT) in the cytoplasm and consequently never reach the synapse.

REFERENCES
[1]Sun H (2012). Capture hydrolysis signals in the microsomal stability assay: molecular mechanisms of the alkyl ester drug and prodrug metabolism. Bioorg Med Chem Lett. 22(2):989-95. PMID 22197392
[2] Ashe KM, Chiu WL, Khalifa AM, Nicolas AN, Brown BL, De Martino RR, Alexander CP, Waggener CT, Fischer-Stenger K, Stewart JK (2011). Vesicular monoamine transporter-1 (VMAT-1) mRNA and immunoreactive proteins in mouse brain. Neuro Endocrinol Lett. 32(3):253-8. PMID 21712771.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of May 14, 2024


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Reserpine, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Alkaloids, Antipsychotics, Hypertension


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