630-93-3 Phenytoin sodium AKSci J10265
 
 
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  J10265    AKSci Reference Standard
Phenytoin sodium, 98%
 
5,5-Diphenyl-2,4-imidazolidinedione
Dilantin
IDENTITY
CAS Number:630-93-3
MDL Number:MFCD00069674
MF:C15H11N2O2Na
MW:274.25
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98%
Physical Form (at 20°C):Solid
Melting Point:295-298°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes and shipment methods. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: 32mg/mL; H2O: 3mg/mL; EtOH: 11mg/mL
Application(s):Inactive voltage-gated sodium channel stabilizer
Form:Sodium salt

REVIEW
 Phenytoin acts on sodium channels on the neuronal cell membrane, limiting the spread of seizure activity and reducing seizure propagation. By promoting sodium efflux from neurons, phenytoin tends to stabilize the threshold against hyperexcitability caused by excessive stimulation or environmental changes capable of reducing membrane sodium gradient. This includes the reduction of post-tetanic potentiation at synapses. Loss of post-tetanic potentiation prevents cortical seizure foci from detonating adjacent cortical areas.

REFERENCES
[1]Balaji S (2004). Medical Therapy for Sudden Death. Pediatric Clinics of North America 51 (5): 1379-1387. doi:10.1016/j.pcl.2004.04.002. PMID 15331289.
[2] Biltz H (1908). ?ber die Konstitution der Einwirkungsprodukte von substituierten Harnstoffen auf Benzil und ?ber einige neue Methoden zur Darstellung der 5,5-Diphenyl-hydantoine [Constitution of the Products of the Interaction of Substituted Carbamides on Benzil and Certain New Methods for the Preparation of 5,5-Diphenylhydantoin] (in German). Chemische Berichte 41 (1): 1379-1393. doi:10.1002/cber.190804101255.
[3] Carl GF, Smith ML (1992). Phenytoin-folate interactions: differing effects of the sodium salt and the free acid of phenytoin. Epilepsia 33 (2): 372-375. doi:10.1111/j.1528-1157.1992.tb02330.x. PMID 1547769.
[4] Adab N, Tudur SC, Vinten J, Williamson P, Winterbottom J (2004). Common Antiepileptic Drugs in Pregnancy in Women with Epilepsy. Cochrane Database of Systematic Reviews 2004 (3): CD004848. doi:10.1002/14651858.CD004848. PMID 15266543.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H317; H361

Precautionary Statements
P201; P202; P261; P264; P270; P272; P280; P301+P312; P302+P352; P308+P313; P321; P330; P333+P313; P363; P405; P501

Current as of May 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Phenytoin sodium, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Anticonvulsants, Arrhythmia


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