144598-75-4 Paliperidone AKSci J10457
 
 
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  J10457    
Paliperidone, >98% (HPLC), powder
 
3-[2-[4-(6-Fluoro-1,2-benzisoxazol-3-yl)-1-piperidinyl]ethyl]-6,7,8,9-tetrahydro-9-hydroxy-2-methyl-4H-pyrido[1,2-a]pyrimidin-4-one
Invega
9-hydroxyrisperidone
IDENTITY
CAS Number:144598-75-4
MDL Number:MFCD00871802
MF:C23H27FN4O3
MW:426.48
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:181-186°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
UN #:UN2811
Hazard Class:6.1; Poison
Packing Group:III
A hazmat fee may apply to certain package sizes. Please check pricing table for an indicator of applicable hazmat fees.

BIOLOGICAL INFO
Solubility:DMSO: >5mg/mL
Application(s):Dopamine Antagonist; Adrenergic receptor antagonist; H1 histamine receptor antagonist
Form:Free Base

REVIEW
 A dopamine antagonist of the atypical antipsychotic class of medications. Paliperidone also has antagonist effect at a1 and a2 adrenergic receptors and at H1 histamine receptors.

REFERENCES
[1]Kozielska M, Johnson M, Pilla Reddy V, Vermeulen A, Li C, Grimwood S, de Greef R, Groothuis GM, Danhof M, Proost JH (2012). Pharmacokinetic-pharmacodynamic modeling of the D2 and 5-HT (2A) receptor occupancy of risperidone and paliperidone in rats. Pharm Res. 29(7):1932-48. PMID 22437487.
[2] Bindu KH, Reddy IU, Anjaneyulu Y, Suryanarayana MV (2012). A stability-indicating ultra-performance liquid chromatographic method for estimation of related substances and degradants in paliperidone active pharmaceutical ingredient and its pharmaceutical dosage forms. J Chromatogr Sci. 50(4):368-72. PMID 22407348.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H301

Precautionary Statements
P264; P270; P301+P310; P321; P330; P405; P501

Current as of April 30, 2024


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CATEGORIES
 APIs and Bioactives > Antipsychotics


PubChem