BMY 26517, 9-Methyl-3-(1H-tetrazol-5-yl)-4H-pyrido[1,2-a]pyrimidin-4-one potassium salt
IDENTITY
CAS Number:
100299-08-9
MDL Number:
MFCD01690051
MF:
C10H7KN6O
MW:
266.3
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:
98%
Physical Form (at 20°C):
Solid
Melting Point:
>300°C
Long-Term Storage:
Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material
BIOLOGICAL INFO
Solubility:
H2O: =18 mg/mL
REVIEW Pemirolast binds to the histamine H1 receptor. This blocks the action of endogenous histamine, which subsequently leads to temporary relief of the negative symptoms brought on by histamine. Pemirolast has also been observed to inhibit antigen-stimulated calcium ion influx into mast cells through the blockage of calcium channels. Pemirolast inhibits the chemotaxis of eosinophils into ocular tissue, and prevents inflammatory mediator release from human eosinophils.
REFERENCES
[1]
Tinkelman DG, Berkowitz RB: A pilot study of pemirolast in patients with seasonal allergic rhinitis. Ann Allergy. 1991 Feb;66(2):162-5.
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