76824-35-6 Famotidine AKSci J10706
 
 
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  J10706    AKSci Reference Standard
Famotidine, >98% (HPLC), powder
 
N'-(Aminosulfonyl)-3-([2-(diaminomethyleneamino)-4-thiazolyl]methylthio)propanamidine
IDENTITY
CAS Number:76824-35-6
MDL Number:MFCD00079297
MF:C8H15N7O2S3
MW:337.45
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:>98% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:160-168°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Water 0.1mg/mL (ultrasonic), DMF 30 mg/ml, DMSO 30 mg/ml, Ethanol slightly soluble
Application(s):Histamine H2-receptor antagonist

REVIEW
 Famotidine binds competitively to H2-receptors located on the basolateral membrane of the parietal cell, blocking histamine affects. This competitive inhibition results in reduced basal and nocturnal gastric acid secretion and a reduction in gastric volume, acidity, and amount of gastric acid released in response to stimuli including food, caffeine, insulin, betazole, or pentagastrin.

REFERENCES
[1]Humphries TJ, Merritt GJ (August 1999). Review article: drug interactions with agents used to treat acid-related diseases. Aliment. Pharmacol. Ther. 13 Suppl 3: 18-26. doi:10.1046/j.1365-2036.1999.00021.x. PMID 10491725.
[2] Pali-Schöll I, Jensen-Jarolim E (April 2011). Anti-acid medication as a risk factor for food allergy. Allergy 66 (4): 469-77. doi:10.1111/j.1398-9995.2010.02511.x. PMID 21121928.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 6, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Antihistamines


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