135459-87-9 Strontium ranelate heptahydrate AKSci J10921
 
 
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  J10921    AKSci Reference Standard
Strontium ranelate heptahydrate, 99% (HPLC)
 
Ranelic acid distrontium salt
IDENTITY
CAS Number:135459-87-9
MDL Number:MFCD12031997
MF:C12H6N2O8SSr2.7H2O
MW:639.60
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC)
Physical Form (at 20°C):Solid
Melting Point:>300°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Bone Density Conservation Agent
Form:Strontium salt

REVIEW
 Strontium ranelate is an antiosteoporotic agent which both increases bone formation and reduces bone resorption, resulting in a rebalance of bone turnover in favor of bone formation. Strontium ranelate stimulates the calcium sensing receptors and leads to the differentiation of pre-osteoblast to osteoblast which increases the bone formation.

REFERENCES
[1]Panahifar A, Maksymowych WP, Doschak MR (2012). Potential mechanism of alendronate inhibition of osteophyte formation in the rat model of post-traumatic osteoarthritis: evaluation of elemental strontium as a molecular tracer of bone formation. Osteoarthritis Cartilage. 20(7):694-702. PMID 22498029.
[2] Reginster JY, Kaufman JM, Goemaere S, Devogelaer JP, Benhamou CL, Felsenberg D, Diaz-Curiel M, Brandi ML, Badurski J, Wark J, Balogh A, Bruyère O, Roux C (2012). Maintenance of antifracture efficacy over 10 years with strontium ranelate in postmenopausal osteoporosis. Osteoporos Int. 23(3):1115-22. PMID 22124575.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302+H312+H332

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P312; P322; P330; P363; P501

Current as of April 30, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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