637-07-0 Clofibrate AKSci J10980
 
 
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  J10980    AKSci Reference Standard
Clofibrate, 99% (GC, HPLC), powder
 
2-(4-Chlorophenoxy)isobutyric acid ethyl ester
Ethyl 2-(4-Chlorophenoxy)isobutyrate
IDENTITY
CAS Number:637-07-0
MDL Number:MFCD00000615
MF:C12H15ClO3
MW:242.7
EINECS:211-277-4
BRN:1913459
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (GC, HPLC), powder
Physical Form (at 20°C):Liquid
Boiling Point:148-156°C
Flash Point:113°C
Density:1.137-1.144
Refractive Index:1.500-1.505
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Clofibrate is a fibric acid derivative used as an antilipidemic agent in the treatment of Primary Dysbetalipoproteinemia (Type III hyperlipidemia) that does not respond adequately to diet. This helps control high cholesterol and high triglyceride levels. Also, clofibrate is an agonist of the PPAR-a receptor[4] in muscle, liver, and other tissues. This agonism ultimately leads to modification in gene expression resulting in increased beta-oxidation, decreased triglyceride secretion, increased HDL, increased lipoprotein lipase activity.

REFERENCES
[1]Bremer, Jon; Osmundsen, Harald; Christiansen, Renata Z.; Borrebaek, Borgar. Clofibrate. Methods in Enzymology. (1981) 72(Lipids, Part D): 506-19.
[2] Backes, James M.; Gibson, Cheryl A.; Ruisinger, Janelle F.; Moriarty, Patrick M. Fibrates: what have we learned in the past 40 years? Pharmacotherapy. (2007) 27(3): 412-424.
[3] Mehendale, Harihara M. PPAR-alpha: a key to the mechanism of hepatoprotection by clofibrate. Toxicological Sciences. (2000) 57(2): 187-190.
[4] Thorp, Jeffrey M. Hypocholesterolemic compositions (1962), GB 898596 19620614.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Danger

Hazard Statements
H302; H315; H318; H335; H411

Precautionary Statements
P261; P264; P270; P271; P273; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P310; P321; P330; P332+P313; P362; P391; P403+P233; P405; P501

Current as of May 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
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WARNING: Attention California residents: This product can expose you to chemicals including Clofibrate, which is known to the State of California to cause cancer. For more information, go to www.P65Warnings.ca.gov.




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