107724-20-9 Eplerenone AKSci J11424
 
 
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  J11424    
Eplerenone, 99% (HPLC), powder
 
9,11alpha-Epoxy-17-hydroxy-3-oxo-17alpha-pregn-4-ene-7alpha,21-dicarboxylic acid
Inspra
IDENTITY
CAS Number:107724-20-9
MDL Number:MFCD07783647
MF:C24H30O6
MW:414.49
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:234-243°C
Optical Rotation:+5° (c=1, CHCl3)
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Application(s):Aldosterone antagonist
Form:Free Base

REVIEW
 Eplerenone binds to the mineralocorticoid receptor and thereby blocks the binding of aldosterone (component of the renin-angiotensin-aldosterone-system, or RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g., kidney) and nonepithelial (e.g., heart, blood vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms.

REFERENCES
[1]Chatterjee, S; Moeller, C; Shah, N; Bolorunduro, O; Lichstein, E; Moskovits, N; Mukherjee, D (2012 Aug). Eplerenone is not superior to older and less expensive aldosterone antagonists.. The American journal of medicine 125 (8): 817-25. PMID 22840667.
[2] Rossi S, editor.Australian Medicines Handbook 2006. Adelaide: Australian Medicines Handbook; 2006
[3] Craft, Jennifer (April 2004). Eplerenone. Eplerenone (Inspra), a new aldosterone antagonist for the treatment of systemic hypertension and heart failure (Pub MedCentral) 17 (2): 217-20. PMC 1200656. PMID 16200104.
[4] Zhang, Bin; Steroids 2011, V76(1-2), P56-59

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of April 30, 2024


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CATEGORIES
 APIs and Bioactives > Steroid Hormones


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