13647-35-3 Trilostane AKSci J40158
 
 
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  J40158    AKSci Reference Standard
Trilostane, 99% (HPLC), powder
 
(4alpha,5alpha,17beta-3,17-dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Vetoryl
IDENTITY
CAS Number:13647-35-3
MDL Number:MFCD00199295
MF:C20H27NO3
MW:329.43
EINECS:237-133-0
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:99% (HPLC), powder
Physical Form (at 20°C):Solid
Melting Point:257-270°C
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO: >=17mg/mL;H 2O: <1mg/mL; EtOH: <1mg/mL
Application(s):Inhibitor of 3 beta-hydroxysteroid dehydrogenase (3-beta-HSD)
Form:Free Base

REVIEW
 Trilostane produces suppression of the adrenal cortex by inhibiting enzymatic conversion of steroids by 3-beta-hydroxysteroid dehydrogenase/delta 5,4 ketosteroid isomerase, thus blocking synthesis of adrenal steroids.

REFERENCES
[1]Komanicky P, Spark RF, Melby JC: Treatment of Cushing's syndrome with trilostane (WIN 24,540), an inhibitor of adrenal steroid biosynthesis. J Clin Endocrinol Metab. 1978 Nov;47(5):1042-51.
[2] Ouschan C, Lepschy M, Zeugswetter F, Möstl E (2012). The influence of trilostane on steroid hormone metabolism in canine adrenal glands and corpora lutea-an in vitro study. Vet Res Commun. 36(1):35-40. PMID 22113849.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H361

Precautionary Statements
P201; P202; P264; P280; P302+P352; P305+P351+P338; P308+P313; P321; P332+P313; P337+P313; P362; P405; P501

Current as of April 30, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.
⚠️

WARNING: Attention California residents: This product can expose you to chemicals including Trilostane, which is known to the State of California to cause birth defects or other reproductive harm. For more information, go to www.P65Warnings.ca.gov.




CATEGORIES
 APIs and Bioactives > Veterinary


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