23239-51-2 Ritodrine HCl AKSci J51776
 
 
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  J51776    
Ritodrine HCl, 95%
 



IDENTITY
CAS Number:23239-51-2
MDL Number:MFCD01657514
MF:C17H21NO3.HCl
MW:323.81
EINECS:245-514-8
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:192-196°C
Boiling Point:512.3°C
Flash Point:175.6°C
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:50mg/1ml of H2O: clear colorless solution
Form:hydrochloride salt

REVIEW
 Ritodrine HCl is an adrenergic beta2 selective agonist used to control premature labor. It binds to beta-2 adrenergic receptors on outer membrane of myometrial cell, activates adenyl cyclase to increase the level of cAMP which decreases intracellular calcium and leads to a relaxation of uterine smooth muscle and, therefore, a decrease in premature uterine contractions.

REFERENCES
[1]Marzo, Antonio; Coa, Katrin; Fontana, Elena; Tavazzi, Simona; Dal Bo, Lorenzo; Ismaili, Shefqet; Zava, Dario; Cantoni, Vittorio; Bertolini, Andrea. Pharmacokinetics and pharmacodynamics of ritodrine hydrochloride administered orally and intramuscularly to female healthy volunteers. Arzneimittel Forschung. (2010) 60(8): 510-518.
[2] Van Dijk, J.; Moed, H. D. Synthesis of beta-phenylethylamine derivatives. X. N-(hydroxy- and methoxyaralkyl) derivatives. Recueil des Travaux Chimiques des Pays-Bas. (1973) 92(12): 1281-97.
[3] Wilson, Kathleen H.; Lauersen, Hiels H.; Raghavan, K. S.; Fuchs, Fritz; Niemann, Wendell H. Effects of diazoxide and beta adrenergic drugs on spontaneous and induced uterine activity in the pregnant baboon. American Journal of Obstetrics and Gynecology. (1974) 118(4): 499-509.
[4] Zanon, Jacopo; Libralon, Giovanna; De Faveri, Carla; Huber, Florian Anton Martin Process for preparation of Ritodrine hydrochloride PCT Int. Appl. (2011), WO 2011134724 A2 20111103.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302

Precautionary Statements
P264; P270; P301+P312; P330; P501

Current as of April 30, 2024


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