145108-58-3 Dexmedetomidine HCl AKSci J57899
 
 
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  J57899    
Dexmedetomidine HCl, 95%
 
Precedex, (S)-5-(1-(2,3-Dimethylphenyl)ethyl)-1H-imidazole hydrochloride
IDENTITY
CAS Number:145108-58-3
MDL Number:MFCD07772269
MF:C13H17ClN2
MW:236.74
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:156-159°C
Optical Rotation:+52.4° (c=1, H2O)
Density:1.17
Long-Term Storage:Store long-term at 2-8°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:Soluble in Water (100 mM), DMSO (100 mM),or Ethanol (25 mM)

REVIEW
 Medetomide''s active isomer which is a potent, highly selective alfa2-adrenoceptor agonist. In vivo; displays hypothermic, hypotensive, bradycardic, anxiolytic, sedative and analgesic effects.

REFERENCES
[1]Fisher et al (1991) Antinociceptive properties of intrathecal dexmedetomidine in rats. Eur.J.Pharmacol. 192 221.
[2] Virtanen et al (1988) Characterization of the selectivity, specificity and potency of medetomidine as an a2-adrenoceptor agonist. Eur.J.Pharmacol. 150 9.
[3] Scheinin et al (1989) Medetomidine - a novel a2-adrenoceptor agonist: a review of its pharmacodynamic effects. Prog.Neuro-Psychopharm.Biol.Psychiat. 13 635.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H302; H315; H319; H335

Precautionary Statements
P261; P264; P270; P271; P280; P301+P312; P302+P352; P304+P340; P305+P351+P338; P312; P321; P330; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
2371AHDexmedetomidine

Current as of May 15, 2024


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