98105-99-8 Sarafloxacin AKSci J93549
 
 
Loading Please Wait...
  J93549    AKSci Bulk Reagent
Sarafloxacin, 95%
 
A-56620
IDENTITY
CAS Number:98105-99-8
MDL Number:MFCD00865974
MF:C20H17F2N3O3
MW:385.36
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:95%
Physical Form (at 20°C):Solid
Melting Point:>300°C
Long-Term Storage:Store long-term in a cool, dry place
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

REVIEW
 Sarafloxacin is a fluoroquinoline antibacterial effective against Mycobacterium tuberculosis once used for prophylactic dosage in poultry and fish, as well as for normal use in human. The compound has shown multimodal mechanism of action and inhibits both DNA gyrase and topoisomerase IV enzyme, leading to increased antibacterial spectrum via DNA gyrase-dependent processes such as DNA polymerization, (ATP-dependent) DNA supercoiling, and chromosome fragmentation. Sarafloxacin was removed from clinical use by the manufacturer (Abbott Laboratories) on April 30, 2001 due to lack of sales.

REFERENCES
[1]Stamm JM, Hanson CW, Chu DT, Bailer R, Vojtko C, Fernandes PB. In vitro evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986 Feb;29(2):193-200.
[2] Fernandes PB, Chu DT, Bower RR, Jarvis KP, Ramer NR, Shipkowitz N. In vivo evaluation of A-56619 (difloxacin) and A-56620: new aryl-fluoroquinolones. Antimicrob Agents Chemother. 1986 Feb;29(2):201-8.
[3] Smith BR, LeFrock JL, Donato JB, Joseph WS, Weber SJ. In vitro activity of A-56619 and A56620, two new aryl-fluoroquinolone antimicrobial agents. Antimicrob Agents Chemother. 1986 Feb;29(2):355-8.
[4] J.F. Bauer, et al.; Determination of temafloxacin, sarafloxacin, and difloxacin in bulk drug and dosage forms by high-performance liquid chromatography. Pharm. Res. 7, 1177 (1990)..

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

RELATED PRODUCTS
A643Sarafloxacin
S303Sarafloxacin hydrochloride

Current as of April 29, 2024


Download SDS Request COA

All products are stocked and shipped from San Francisco Bay Area, California, USA.

⚠️
All products are for research and development use only, not for any other uses, and must be handled by technically-qualified persons.

These products are explicitly not intended to be used in foods and/or cosmetics and/or drugs (human and veterinary) and/or consumer products and/or biocides and/or pesticides of any kind unless explicitly stated otherwise.

Products are not sold to individuals. We do not ship to residential addresses. Consumer orders will be cancelled without notice.

New customers undergo an internal onboarding process. As part of this process, new customers may be asked for more information. Additional restrictions may apply.


CATEGORIES
 APIs and Bioactives > Antibacterials, Quinolones, Veterinary


PubChem
  @PubMed