K917 19-Nor-androst-5(10)-ene-3,17-dione - AK Scientific
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  Catalog ID # K917
, 98%

CAS Registry #:[3962-66-1]
MDL Number:MFCD00271641
Physical Form:Slightly yellow powder
Melting Point:145-150 °C
Optical Rotation:+280 °(CHCl3)
Shipping:Normal Temperature


 19-Nor-androst-5(10)-ene-3,17-dione (Estr-5(10)-ene-3,17-dione) is a steroidal diketone used as a key intermediate in the preparation of 17-alpha-fluorosteroids, mibolerone, androgens, steroidal diketals and dienols.

[1]Hagiwara, Hikoichi; Noguchi, Shunsaku; Nishikawa, Masamoto. Syntheses of 19-nor-3-oxo steroids. Chemical & Pharmaceutical Bulletin. (1960) 8: 84-5.
[2] Bednarski, Patrick J.; Nelson, Sidney D. Interactions of thiol-containing androgens with human placental aromatase. Journal of Medicinal Chemistry. (1989) 32(1): 203-13.
[3] Yang, Qing; Fan, Bo-lin; Tang, Rui-ren. Synthesis and characterization of mibolerone. Journal of Central South University of Technology (English Edition). (2007) 14(4): 524-527.
[4] Hagiwara, Hikoichi Steroid. XVIII. Synthesis of 3-oxo-19-nor steroids Yakugaku Zasshi (1960), 80, 1675-9.
[5] Nishikawa, Masamoto; Hagiwara, Hikoiehi 10-Carboxy-4-androstenes (1961), US 3014931 19611226.
[6] Templeton, John F.; Ling, Yangzhi; Lin, Weiyang; Majgier-Baranowska, Helena; Marat, Kirk 19-Hydroxy-5beta,19-cyclosteroids: synthesis, isomerization and ring opening Journal of the Chemical Society, Perkin Transactions 1: Organic and Bio-Organic Chemistry (1997), (12), 1895-1904.
[7] 19-Norsteroid ketals (1962), BE 619037 19621217.
[8] Whitten, Jeffrey P.; Benson, Harvey D.; Rand, Cynthia L.Process for the preparation of 10-(2-propynyl)estr-4-ene-3,17-dione Eur. Pat. Appl. (1991), EP 459381 A2 19911204.
[9] Budesinsky, Milos; Fajkos, Jan; Guenter, Jaroslav; Kasal, Alexander Synthesis, reactions, conformation analysis, and NMR spectra of 5,10-epoxy-5?,10?-estrane-3,17-diones Collection of Czechoslovak Chemical Communications (2005), 70(4), 507-518.
[10] Blotny, Grzegorz; Pollack, Ralph M.Synthesis of conjugated dienol phosphates Synthesis (1988), (2), 109- 11
[11] Bothe, Ulrich; Droescher, Peter; Elger, Walter; Reddersen, Gudrun; Menzenbach, Bernd; Schweikert, Hans-udo; Hillisch, Alexander; Schneider, Birgett Preparation of 17-alpha-fluorosteroids for use treating prostate-related conditions U.S. Pat. Appl. Publ. (2005), US 20050234027 A1 20051020.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.

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 APIs and Bioactives > Steroid Hormones