REVIEW Sclareol is a fragrant, bicyclic diterpene alcohol found in the sage plant Salvia sclarea. It is used as a fragrance in cosmetics and perfumes and as a flavoring in food. It has been shown to kill human leukemic cells and colon cancer cells by apoptosis.
REFERENCES
[1]
Volmar, Y.; Jermstad, A. Sclareol, the principal constituent of the absolute essence of clary sage Compt. rend. (1928), 186, 783-5.
[2]
Barltrop, J. A.; Bigley, D. B.; Rogers, N. A. J. Synthesis of sclareol and 13-episclareol Chemistry & Industry (London, United Kingdom) (1959), 400-1.
[3]
Schalk, Michel; Pastore, Laurence; Mirata, Marco A.; Khim, Samretthy; Schouwey, Marina; Deguerry, Fabienne; Pineda, Virginia; Rocci, Letizia; Daviet, Laurent Toward a Biosynthetic Route to Sclareol and Amber Odorants Journal of the American Chemical Society (2012), 134(46), 18900-18903.
[4]
Dimas K, Kokkinopoulos D, Demetzos C, Vaos B, Marselos M, Malamas M, Tzavaras T.The effect of sclareol on growth and cell cycle progression of human leukemic cell lines. Leuk Res. 1999 Mar;23(3):217-34.
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