Q790 Desoximetasone - AK Scientific
 
 
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  Catalog ID # Q790
Desoximetasone
, 97%
 
9-Fluoro-11?,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione




IDENTITY
CAS Registry #:[382-67-2]
MDL Number:MFCD00083301
MF:C22H29FO4
MW:376.46
SPECIFICATIONS & PROPERTIES
Purity:97%
Physical Form:White powder
Melting Point:212-233°C
Optical Rotation:109 °(chloroform)
Shipping:Normal Temperature

REVIEW

 Desoximetasone is a synthetic topical corticosteroid, used as anti-inflammatory and anti-pruritic agents. It is used for the relief of various skin conditions, including rashes, reducing redness, itching, and irritation - dermatoses, skin allergies, psoriasis. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.

REFERENCES
[1]Borelli C, Gassmueller J, Fluhr JW, Nietsch KH, Schinzel S, Korting HC. Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay. Skin Pharmacol Physiol. (2008) 21(3): 181-7.
[2] Kircik L, Lebwohl MG, Del Rosso JQ, Bagel J, Stein Gold L, Weiss JS. Clinical study results of desoximetasone spray, 0.25% in moderate to severe plaque psoriasis. J Drugs Dermatol. (2013) Dec;12(12): 1404-10.
[3] Heel, R. C.; Brogden, R. N.; Speight, T. M.; Avery, G. S. Desoxymethasone: a review of its pharmacological properties and therapeutic efficacy in the treatment of dermatoses. Drugs. (1978) 16(4): 302-21.
[4] Hydroxy steroids for coronary spasms (1962), FR M335 19620108.
[5] Jolly, Robert; Warnant, Julien; Goffinet, Bernard 9alpha-Fluoro corticosteroids (1962), FR 1296544 19620622.
[6] 16alpha-Methyl steroids (1962), BE 614196 19620821.
[7] Joly, R.; Warnant, J.; Goffinet, B.; Jelly, J.; Prost-Marechal, J.Synthesis of 9alpha-fluoro-16-methyl-17-deoxyprednisolone Arzneimittel-Forschung (1974), 24(1), 1-3.
[8] Lange K; Kleuser B; Gysler A; Bader M; Maia C; Scheidereit C; Korting H C; Schafer-Korting M Cutaneous inflammation and proliferation in vitro: differential effects and mode of action of topical glucocorticoids Skin pharmacology and applied skin physiology (2000), 13(2), 93-103
[9] Ehrlich E N; Nolten W E; Lindheimer M D Mineralocorticoids and the regulation of sodium metabolism in normal and hypertensive pregnancy: a review Clinical and experimental hypertension (1980), 2(5), 803-19
[10] Savin RC.Desoximetasone--a new topical corticosteroid: short- and long-term experiences. Cutis. 1978 Mar;21(3):403-7.
[11] Willis I, Cornell RC, Penneys NS, Zaias N.Multicenter study comparing 0.05% gel formulations of desoximetasone and fluocinonide in patients with scalp psoriasis. Clin Ther. 1986;8(3):275-82.
[12] Levitt J, Feldman T, Riss I, Leung OT.Compatibility of desoximetasone and tacrolimus. J Drugs Dermatol. 2003 Dec;2(6):640-2.
[13] Hebert AA, Koo J, Fowler J, Berman B, Rosenberg C, Levitt J.Desoximetasone 0.25% and tacrolimus 0.1% ointments versus tacrolimus alone in the treatment of atopic dermatitis. Cutis. 2006 Nov;78(5):357-63.
[14] Baehr, V.; Oelkers, W.; Pfeiffer, A. F. H.; Diederich, S.Metabolism of synthetic steroids by the human placenta Placenta (2007), 28(5-6), 588-589.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem