Q790 Desoximetasone - AK Scientific
 
 
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  Catalog ID # Q790
Desoximetasone
, 97%
 
9-Fluoro-11?,21-dihydroxy-16a-methylpregna-1,4-diene-3,20-dione




IDENTITY
CAS Registry #:[382-67-2]
MDL Number:MFCD00083301
MF:C22H29FO4
MW:376.46
SPECIFICATIONS & PROPERTIES
Purity:97%
Physical Form:White powder
Melting Point:212-233°C
Optical Rotation:109 °(chloroform)
Shipping:Normal Temperature

REVIEW

 Desoximetasone is a synthetic topical corticosteroid, used as anti-inflammatory and anti-pruritic agents. It is used for the relief of various skin conditions, including rashes, reducing redness, itching, and irritation - dermatoses, skin allergies, psoriasis. It is postulated that these proteins control the biosynthesis of potent mediators of inflammation such as prostaglandins and leukotrienes by inhibiting the release of their common precursor arachidonic acid.

REFERENCES
[1]Borelli C, Gassmueller J, Fluhr JW, Nietsch KH, Schinzel S, Korting HC. Activity of different desoximetasone preparations compared to other topical corticosteroids in the vasoconstriction assay. Skin Pharmacol Physiol. (2008) 21(3): 181-7.
[2] Kircik L, Lebwohl MG, Del Rosso JQ, Bagel J, Stein Gold L, Weiss JS. Clinical study results of desoximetasone spray, 0.25% in moderate to severe plaque psoriasis. J Drugs Dermatol. (2013) Dec;12(12): 1404-10.
[3] Heel, R. C.; Brogden, R. N.; Speight, T. M.; Avery, G. S. Desoxymethasone: a review of its pharmacological properties and therapeutic efficacy in the treatment of dermatoses. Drugs. (1978) 16(4): 302-21.
[4] Hydroxy steroids for coronary spasms (1962), FR M335 19620108.

Risk Description(s)
R36/37/38:Irritating to eyes, respiratory system and skin

Safety Description(s)
S24/25:Avoid contact with skin and eyes.


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CATEGORIES

 APIs and Bioactives > Steroid Hormones

USEFUL LINKS

  PubChem