R853 (+/-)-Verapamil hydrochloride - AK Scientific
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  Catalog ID # R853
(+/-)-Verapamil hydrochloride
, 98%

CAS Registry #:[152-11-4]
MDL Number:MFCD00055208
Physical Form:White to off-white crystalline powder
Melting Point:140-144°C
Shipping:Normal Temperature

Application(s):Class IV anti-arrhythmia agent


 Verapamil is a phenylalkylamine L-type calcium channel blocker. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and, more recently, cluster headaches and is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. _x005F_x000D_ Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thus reducing heart rate and blood pressure.

[1]Basic substituted phenylacetonitriles Belg. (1962), BE 615861 A1 19621001.
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[3] Dengel, Ferdinand Method for preparation of basically substituted phenylacetonitriles Ger. (1963), DE 1154810 B 19630926.
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Risk Description(s)
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed

Safety Description(s)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

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 APIs and Bioactives > Arrhythmia, Calcium Channel Blockers


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