R853 (+/-)-Verapamil hydrochloride - AK Scientific
 
 
Loading Please Wait...
  Catalog ID # R853
(+/-)-Verapamil hydrochloride
, 98%
 



IDENTITY
CAS Registry #:[152-11-4]
MDL Number:MFCD00055208
MF:C27H39ClN2O4
MW:491.06
EINECS:205-800-5
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white crystalline powder
Melting Point:140-144°C
Shipping:Normal Temperature
UN #:2811
Hazard Class:6.1
Packing Group:III

BIOLOGICAL INFO
Application(s):Class IV anti-arrhythmia agent

REVIEW

 Verapamil is a phenylalkylamine L-type calcium channel blocker. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and, more recently, cluster headaches and is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thus reducing heart rate and blood pressure.

REFERENCES
[1]Basic substituted phenylacetonitriles Belg. (1962), BE 615861 A1 19621001.
[2] Appel, Walter alpha-Isopropyl-alpha-[gamma-(N-methyl-N-homoveratrylamino)propyl]-alpha-(3,4-dimethoxyphenyl)acetonitrile, its determination in biological material and its activity in blood Arzneimittel-Forschung (1962), 12, 562.
[3] Dengel, Ferdinand Method for preparation of basically substituted phenylacetonitriles Ger. (1963), DE 1154810 B 19630926.
[4] Guerrero JR, Martin SS.

Risk Description(s)
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed

Safety Description(s)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



Pricing (not showing? please refresh your web browser)

*HAZMAT SHIPPING
*For reference only. Please do not use in place of local hazmat regulations.

*CURRENT AS OF: March 6, 2015
*IN STOCK: Submit your order by 4PM PT, ships today.
*BACKORDERED: Please contact us.
*If Bulk(kg) is "Backordered", there may be sizes less than 1kg available.
*All prices are FOB Union City, CA, USA.


SDS

 R853_SDS.pdf

CATEGORIES

 APIs and Bioactives > Arrhythmia, Calcium Channel Blockers

USEFUL LINKS

  PubChem  @PubMed