R853 (+/-)-Verapamil hydrochloride - AK Scientific
 
 
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  Catalog ID # R853
(+/-)-Verapamil hydrochloride
, 98%
 



IDENTITY
CAS Registry #:[152-11-4]
MDL Number:MFCD00055208
MF:C27H38N2O4.HCl
MW:491.068
EINECS:205-800-5
SPECIFICATIONS & PROPERTIES
Purity:98%
Physical Form:White to off-white crystalline powder
Melting Point:140-144°C
Shipping:Normal Temperature

BIOLOGICAL INFO
Application(s):Class IV anti-arrhythmia agent

REVIEW

 Verapamil is a phenylalkylamine L-type calcium channel blocker. It has been used in the treatment of hypertension, angina pectoris, cardiac arrhythmia, and, more recently, cluster headaches and is also an effective preventive medication for migraine. Verapamil has also been used as a vasodilator during cryopreservation of blood vessels. Verapamil's mechanism in all cases is to block voltage-dependent calcium channels. Specifically, its effect on L-type calcium channels in the heart causes a reduction in ionotropy and chronotropy, thus reducing heart rate and blood pressure.

REFERENCES
[1]Basic substituted phenylacetonitriles Belg. (1962), BE 615861 A1 19621001.
[2] Appel, Walter alpha-Isopropyl-alpha-[gamma-(N-methyl-N-homoveratrylamino)propyl]-alpha-(3,4-dimethoxyphenyl)acetonitrile, its determination in biological material and its activity in blood Arzneimittel-Forschung (1962), 12, 562.
[3] Dengel, Ferdinand Method for preparation of basically substituted phenylacetonitriles Ger. (1963), DE 1154810 B 19630926.
[4] Guerrero JR, Martin SS.
[5] Vohra J. Verapamil in cardiac arrhythmias: an overview. Clin Exp Pharmacol Physiol Suppl. 1982;6:129-34.
[6] Baky SH, Singh BN. Verapamil hydrochloride: pharmacological properties and role in cardiovascular therapeutics. Pharmacotherapy. 1982 Nov-Dec;2(6):328-353.
[7] Ruedy J. Verapamil. Clin Invest Med. 1981;4(2):129-47.
[8] Singh BN, Ellrodt G, Peter CT. Verapamil: a review of its pharmacological properties and therapeutic use. Drugs. 1978 Mar;15(3):169-97.
[9] Vohra JK. Clinical use of verapamil. Drugs. 1977 Mar;13(3):219-24.
[10] Nayler WG, Krikler D.Verapamil and the myocardium.Postgrad Med J. 1974 Jul;50(585):441-6.
[11] Bellamy WT: P-glycoproteins and multidrug resistance. Annu Rev Pharmacol Toxicol. 1996;36:161-83.

Risk Description(s)
R23/24/25:Toxic by inhalation, in contact with skin and if swallowed

Safety Description(s)
S36/37/39:Wear suitable protective clothing, gloves and eye/face protection.
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).



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CATEGORIES

 APIs and Bioactives > Calcium Channel Blockers

USEFUL LINKS

  @PubChem  @PubMed  @Wikipedia