V0371 Rutaecarpine - AK Scientific
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  Catalog ID # V0371
, 98%

CAS Registry #:[84-26-4]
MDL Number:MFCD00210551
Physical Form:White to yellow powder
Melting Point:258-266°C
Long-Term Storage:Store at 2-8°C
Shipping:Normal Temperature

Solubility:DMSO: 18 mg/mL clear yellow solution; H2O: insoluble.
Application(s):Indolopyridoquinazolinone alkaloid


 Rutecarpine (rutaecarpine) is a indolopyridoquinazoline alkaloid isolated from Evodia rutaecarpa (Wu-Chu-Yu) which remains the most popular and multi-purpose herb traditionally used in China for treatment of headache, abdominal pain, postpartum hemorrhage, dysentery and amenorrhea. Rutaecarpine is one of the intriguing indolopyridoquinazoline alkaloids isolated from Wu-Chu-Yu. Rutaecarpine has been shown to have cardiovascular biological effects such as inotropic and chronotropic, vasorelaxant, anti-platelet aggregation and anti-inflammatory effects. Furthermore, it has been reported that rutaecarpine has beneficial effects on some cardiovascular diseases. Rutecarpine has also been shown to be a COX-2 inhibitor.

[1]Wang GJ, Shan J, Pang PK, Yang MC, Chou CJ, Chen CF. The vasorelaxing action of rutaecarpine: direct paradoxical effects on intracellular calcium concentration of vascular smooth muscle and endothelial cells. J Pharmacol Exp Ther. 1996 Mar;276(3):1016-21.
[2] Sheu JR, Hung WC, Lee YM, Yen MH. Mechanism of inhibition of platelet aggregation by rutaecarpine, an alkaloid isolated from Evodia rutaecarpa. Eur J Pharmacol. 1996 Dec 30;318(2-3):469-75.
[3] Sheu JR, Kan YC, Hung WC, Su CH, Lin CH, Lee YM, Yen MH. The antiplatelet activity of rutaecarpine, an alkaloid isolated from Evodia rutaecarpa, is mediated through inhibition of phospholipase C. Thromb Res. 1998 Oct 15;92(2):53-64.
[4] Moon TC, Murakami M, Kudo I, Son KH, Kim HP, Kang SS, Chang HW. A new class of COX-2 inhibitor, rutaecarpine from Evodia rutaecarpa. Inflamm Res. 1999 Dec;48(12):621-5.
[5] Woo HG, Lee CH, Noh MS, Lee JJ, Jung YS, Baik EJ, Moon CH, Lee SH. Rutaecarpine, a quinazolinocarboline alkaloid, inhibits prostaglandin production in RAW264.7 macrophages. Planta Med. 2001 Aug;67(6):505-9.
[6] Wu SN, Lo YK, Chen H, Li HF, Chiang HT. Rutaecarpine-induced block of delayed rectifier K+ current in NG108-15 neuronal cells. Neuropharmacology. 2001 Dec;41(7):834-43.
[7] Hu CP, Xiao L, Deng HW, Li YJ. The cardioprotection of rutaecarpine is mediated by endogenous calcitonin related-gene peptide through activation of vanilloid receptors in guinea-pig hearts. Planta Med. 2002 Aug;68(8):705-9.
[8] Deng PY, Ye F, Cai WJ, Tan GS, Hu CP, Deng HW, Li YJ. Stimulation of calcitonin gene-related peptide synthesis and release: mechanisms for a novel antihypertensive drug, rutaecarpine. J Hypertens. 2004 Sep;22(9):1819-29.
[9] Lee SH, Son JK, Jeong BS, Jeong TC, Chang HW, Lee ES, Jahng Y.Progress in the studies on rutaecarpine. Molecules. 2008 Feb 6;13(2):272-300.
[10] Jia S, Hu C. Pharmacological effects of rutaecarpine as a cardiovascular protective agent. Molecules. 2010 Mar 15;15(3):1873-81.
[11] Li YJ, Zhang F, Gong QH, Wu Q, Yu LM, Sun AS Rutaecarpine inhibits angiotensin II-induced proliferation in rat vascular smooth muscle cells. Chin J Integr Med. 2013 Jun 17.

Risk Description(s)
R25:Toxic if swallowed.

Safety Description(s)
S45:In case of accident or if you feel unwell, seek medical advice immediately (show the label where possible).

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