857064-38-1 WP1066 AKSci X5924
 
 
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  X5924    AKSci Reference Standard
WP1066, 98% (HPLC)
 
(S,E)-3-(6-bromopyridin-2-yl)-2-cyano-N-(1-phenylethyl)acrylamide
IDENTITY
CAS Number:857064-38-1
MDL Number:MFCD12912450
MF:C17H14BrN3O
MW:356.22
SPECIFICATIONS & PROPERTIES
Min. Purity Spec:98% (HPLC)
Physical Form (at 20°C):Solid
Long-Term Storage:Store long-term at -20°C
DOT/IATA TRANSPORT INFORMATION
Not hazardous material

BIOLOGICAL INFO
Solubility:DMSO 72 mg/mL, Water or Ethanol <1 mg/mL
Application(s):JAK
Form:Free base
Research Area:Renal cancer, malignant glioma, leukemia

REVIEW
 WP1066 inhibits JAK2 and its downstream signal transducer and activator of transcription-3 (STAT3), signal transducer and activator of transcription-5 (STAT5), and extracellular signal-regulated kinase-1/2 pathways (ERKs) in a dose- and time-dependent manner. The compound has also been show to suppress proliferation and induce apoptosis in erythroid human cells carrying the JAK2 V617F mutation.

REFERENCES
[1]Priebe, Waldemar; Donato, Nicholas; Talpaz, Moshe; Szymanshi, Slawomir; Fokt, Izabela; Levitki, Alexander Preparation of benzyl cyanocinnamides and related compounds for treatment of cell proliferative diseases PCT Int. Appl. (2005), WO 2005058829 A1 20050630.
[2] Donato, Nicholas J.; Maxwell, David; Talpaz, Moshe; Bornmann, William; Peng, Zhenghong; Pal, Ashutosh; Han, Dongmei; Wang, Shimei; Bartholomeusz, Geoffrey; Kapuria, Vaibhav Tyrphostin derivatives, processes for preparing them, pharmaceutical compositions containing them, and their use as signaling protein modulators PCT Int. Appl. (2008), WO 2008005954 A2 20080110.
[3] Ferrajoli, Alessandra; Faderl, Stefan; Van, Quin; Koch, Patricia; Harris, David; Liu, Zhiming; Hazan-Halevy, Inbal; Wang, Yongtao; Kantarjian, Hagop M.; Priebe, Waldemar; et al WP1066 Disrupts Janus Kinase-2 and Induces Caspase-Dependent Apoptosis in Acute Myelogenous Leukemia Cells Cancer Research (2007), 67(23), 11291-11299.
[4] Verstovsek S, Manshouri T, Quintás-Cardama A, Harris D, Cortes J, Giles FJ, Kantarjian H, Priebe W, Estrov Z WP1066, a novel JAK2 inhibitor, suppresses proliferation and induces apoptosis in erythroid human cells carrying the JAK2 V617F mutation. Clin Cancer Res. 2008 Feb 1;14(3):788-96.

GLOBALLY HARMONIZED SYSTEM (GHS)

Pictograms

Signal Word
Warning

Hazard Statements
H315; H319; H335

Precautionary Statements
P261; P264; P271; P280; P302+P352; P304+P340; P305+P351+P338; P312; P321; P332+P313; P337+P313; P362; P403+P233; P405; P501

Current as of May 15, 2024

AKSci Reference Standards are high-purity, low-impurity compounds suitable for use as standards.


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CATEGORIES
 APIs and Bioactives > Chemotherapeutics


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