REVIEW Alvocidib (flavopiridol) is a synthetic flavone. It is a cyclin-dependent kinase inhibitor and inhibits progression of cells through the cell cycle leading to cell proliferation. It inhibit CDKs including CDK1, CDK2, CDK4 and CDK6 with IC50 values of approximately 40 nM. It is 7.5-fold more selective for CDK1, 2, 4, 6 versus CDK7.
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